Table 3

Incidence of biliary disease associated with type 2 diabetes stratified by age and sex from a retrospective claims database study, 2000–2005

Nondiabetic cohort
Type 2 diabetic cohort
IRR: type 2 diabetic cohort vs. nondiabetic cohort (95% CI)
n*Incident casesPerson-years of follow-upIncidence rate per 100,000 person-years (95% CI)nIncident casesPerson-years of follow-upIncidence rate per 100,000 person-years (95% CI)
Overall age333,5294,019545,088.58737.31 (714.52–760.11)330,7428,322589,693.441,411.24 (1,380.92–1,441.56)1.91 (1.84–1.99)
    18–30 years13,5577216,884.62426.42 (327.92–524.92)13,35430919,217.661,607.90 (1,428.61–1,787.18)3.77 (2.92–4.87)
    31–44 years78,030599119,453.07501.45 (461.29–541.61)77,2221,574130,181.101,209.08 (1,149.35–1,268.82)2.41 (2.19–2.65)
    45–54 years119,3561,300197,277.31658.97 (623.15–694.79)118,3552,839212,090.871,338.58 (1,289.34–1,387.82)2.03 (1.90–2.17)
    55–64 years90,9421,286151,221.24850.41 (803.93–896.89)90,3352,357162,847.331,447.37 (1,388.94–1,505.80)1.70 (1.59–1.82)
    ≥65 years31,64476260,252.341,264.68 (1,174.88–1,354.48)31,4761,24365,356.481,901.88 (1,796.15–2,007.61)1.50 (1.37–1.65)
Sex
    Female147,0732,179237,325.48918.15 (879.60–956.70)145,5574,387258,394.281,697.79 (1,647.55–1,748.03)1.85 (1.76–1.95)
    Male186,4561,840307,763.11597.86 (570.54–625.18)185,1853,935331,299.161,187.75 (1,150.64–1,224.86)1.99 (1.88–2.10)
  • *Biliary disease was defined as occurrence of cholelithiasis, acute cholecystitis, or cholecystectomy. Patients with biliary disease (n = 2,911 from the nondiabetic cohort and n = 5,173 from the type 2 diabetic cohort) or chronic cholecystitis (n = 452 from the nondiabetic cohort and n = 890 from the type 2 diabetic cohort) during the 1-year baseline period were excluded from the numerator and the denominator. Note that some patients may have had more than one exclusionary event.