Table 1

Glucose and insulin concentrations during an OGTT following ingestion of chlorogenic acid, decaffeinated coffee, trigonelline, or placebo in 15 healthy overweight men

Glucose (mmol/l)
Insulin (pmol/l)
−30 minTime 015 min30 min60 min90 min120 minAUC (mmol/l × 120 min)−30 minTime 015 min30 min60 min90 min120 minAUC(pmol/l × 120 min)
Placebo5.7 ± 0.25.6 ± 0.27.7 ± 0.38.8 ± 0.58.7 ± 0.78.1 ± 0.76.8 ± 0.6962 ± 13470.3 ± 9.963.3 ± 9.1384.0 ± 48.9572.7 ± 79.7513.6 ± 71.0489.5 ± 94.6367.5 ± 98.154,727 ± 21,658
Chlorogenic acid5.5 ± 0.15.5 ± 0.17.0 ± 0.2*8.6 ± 0.38.2 ± 0.67.4 ± 0.76.9 ± 0.6912 ± 13467.0 ± 9.656.7 ± 10.1*310.7 ± 55.7*491.2 ± 74.6521.1 ± 101.2480.2 ± 142.2407.2 ± 118.052,285 ± 21,658
Decaffeinated coffee5.6 ± 0.25.6 ± 0.17.6 ± 0.29.2 ± 0.38.9 ± 0.77.7 ± 0.76.6 ± 0.7958 ± 13463.3 ± 9.665.0 ± 9.9331.6 ± 34.4511.9 ± 51.7535.5 ± 73.5463.5 ± 106.8358.4 ± 111.952,324 ± 21,658
Trigonelline5.6 ± 0.15.5 ± 0.17.2 ± 0.2*9.0 ± 0.38.7 ± 0.57.9 ± 0.66.9 ± 0.6952 ± 13461.6 ± 7.653.9 ± 9.5267.0 ± 27.5*501.0 ± 82.0580.3 ± 113.6495.6 ± 83.3361.3 ± 91.253,380 ± 21,658
  • Data are means ± SE unless otherwise indicated. Baseline values are fasting concentrations and were determined right before supplement ingestion; Time 0 was half an hour after supplement ingestion and right before the start of the OGTT.

  • *P < 0.05 using pairedt tests compared with the placebo value. AUC, area under the curve.