Table 3

Major clinical events in type 2 diabetic patients with renal insufficiency stratified by attainment of ≥3 prespecified treatment targets after 2 years of follow-up

Attained ≥3 treatment goals*Attained ≤2 treatment goals*P
Composite primary end point14340.04
ESRD (Cr >500 μmol/l)10210.14
Composite cardiovascular end point19210.22
Hospitalization for heart failure12160.77
Hospitalization for arrhythmia420.41
Acute myocardial infarction350.97
Revascularization (PTCA/CABG)110.83
Hospitalization for angina010.31
Other revascularization010.99
Lower-limb amputation100.14
  • Data are n.

  • *Treatment targets: 1) blood pressure <130/80 mmHg, 2) A1C <7%, 3) LDL cholesterol <2.6 mmol/l, 4) fasting plasma triglyceride <2 mmol/l, and 5) treatment with ACE inhibitors and/or ARBs.

  • †After adjustment for age, sex, and study centers. CABG, coronary artery bypass graft; Cr, serum creatinine; PTCA, percutaneous transluminal coronary angioplasty.