Table 3

Baseline lipoprotein levels and percent change from baseline by triglyceride subgroup

ParameterBaseline triglyceride <2.26 mmol/l
Baseline triglyceride ≥2.26 mmol/l
Week 6
Week 12
Week 6
Week 12
RSV10ATV10PlaceboRSV20ATV20RSV10ATV10PlaceboRSV20ATV20
n66642280585637338633
HDL-C (mmol/l)1.11.21.31.11.11.1
    % change7*3−19§312§441411
HDL-P (μmol/l)282932292930
    % change12*8215§5141362119
ApoA-I (mg/dl)149148152158156154
    % change40.023615§−2164
LDL-C (mmol/l)165168162171176173
    % change−47§−39−3−52−46−43−372−49§−42
Non-HDL-C (mmol/l)5.05.04.85.65.85.7
    % change−44−37−2−49−43−43−371−48−42
LDL-P (nmol/l)1,8121,7361,6912,1402,1002,236
    % change−33−29−1−37−32−37−30−2−40−35
ApoB (mg/dl)152153146169175176
    % change−38−331−43−37−37−35−1−42−37
VLDL-P (nmol/l)958986126130117
    % change−39−40−5−42−44−29−33−4−40−40
Triglycerides (mmol/l)1.81.71.73.02.93.0
    % change−15*−221−18−24−30−26−7−30−31
  • *P< 0.05 vs. placebo.

  • P< 0.01 vs. placebo.

  • P< 0.001 vs. placebo.

  • §P< 0.01 vs. ATV.

  • P< 0.05 vs. ATV.

  • ¶A triglyceride concentration of 2.26 mmol/l corresponds to 200 mg/dl. HDL-C, HDL cholesterol; HDL-P, HDL particle concentration; LDL-C, LDL cholesterol; LDL-P, LDL particle concentration; non-HDL-C, non-HDL cholesterol; VLDL-P, VLDL particle concentration.