Table 1

Baseline characteristics of the analyzed subset of the Inter99 cohort

ConvertersNonconvertersP
Participants160472
Male sex110 (68.8)279 (59.1)0.031
NFG and NGT12 (7.6)226 (49.7)<0.0001
IFG only46 (29.1)174 (38.2)0.0433
IGT only25 (15.8)19 (4.2)<0.0001
Both IFG and IGT75 (47.5)36 (7.9)<0.0001
Family history48 (30.0)98 (20.8)0.0223
Age (years)50.2 (45.2–55.0)49.8 (44.8–54.8)<0.0001
Height (cm)172 (166–179)172 (166–179)0.9277
Weight (kg)89 (80–100)84 (77–93)0.0001
BMI (kg/m2)29.7 (27.5–32.9)27.6 (26.1–30.1)<0.0001
Waist circumference (cm)97 (91–109)93 (86–99)<0.0001
Hip circumference (cm)106 (102–113)104 (100–109)0.004
Systolic blood pressure (mmHg)140 (130–150)130 (120–144)<0.0001
Diastolic blood pressure (mmHg)90 (80–96)85 (80–90)0.0008
Fasting serum total cholesterol (mmol/l)5.8 (5.1–6.5)5.7 (5.0–6.4)0.2513
Fasting serum HDL cholesterol (mmol/l)1.2 (1.0–1.4)1.3 (1.1–1.6)0.0013
Fasting serum LDL cholesterol (mmol/l)3.6 (3.1–4.4)3.6 (3.1–4.3)0.6898
Fasting serum triglycerides (mmol/l)1.6 (1.3–2.2)1.3 (0.9–1.8)<0.0001
Fasting serum insulin (pmol/l)58 (37–81)40 (27–59)<0.0001
2-h serum insulin (pmol/l)325 (210–486)186 (100–298)<0.0001
FPG (mmol/l)6.1 (5.7–6.5)5.6 (5.3–6.0)<0.0001
2-h plasma glucose (mmol/l)8.4 (7.1–9.5)6.1 (5.1–7.0)<0.0001
A1C (%)6.1 (5.8–6.4)5.9 (5.6–6.1)<0.0001
Adiponectin (μg/ml)19.5 (9.3–39.6)22.2 (12.9–42.6)0.0345
CRP (μg/ml)3.2 (1.5–7.9)2.0 (0.8–5.3)<0.0001
Ferritin (ng/ml)867 (290–1749)483 (168–1045)<0.0001
IL-2RA (pg/ml)290 (230–400)270 (200–350)0.0049
  • Data are n (%) or median (interquartile range) for continuous variables. Data are from 632 subjects in the subsample of 3,032 at-risk individuals with BMI ≥25 kg/m2 and age ≥39 years from the Inter99 cohort. Converters are individuals who developed epidemiologically defined diabetes within 5 years. Nonconverters were randomly selected from the Inter99 cohort in an approximately 3:1 ratio to converters. IFG was defined as FPG of 5.6–6.9 mmol/l. Impaired glucose tolerance (IGT) was defined as 2-h postload glucose of 7.8–11.1 mmol/l. At baseline, 92% of the converters had IFG, IGT, or both, whereas 50% of nonconverters had IFG, IGT, or both. For categorical descriptors, values are counts (percentage of total for that cohort). Differences in frequency between converters and nonconverters were evaluated with a Monte Carlo estimation of the χ2 statistic (2,000 replicates). Differences in medians were evaluated with a Wilcoxon test. NFG, normal fasting glucose; NGT, normal glucose tolerance.