Table 2

Systemic immune mediator concentrations in patients with and without diabetic foot ulcer

Immune mediatorPatients with ulcerPatients without ulcerP
CRP (mg/l)11.7 (3.3; 38.2)2.4 (1.0; 5.0)<0.0001
Fibrinogen (g/l)5.5 ± 1.63.8 ± 0.9<0.0001
IL-6 (pg/ml)12.4 (6.9; 30.3)3.8 (2.2; 5.2)<0.0001
MIF (ng/ml)7.7 (5.6; 11.9)4.3 (3.1; 6.6)<0.0001
IL-18 (pg/ml)118.3 (84.2; 179.0)122.7 (85.0; 172.0)NS
IL-8 (pg/ml)11.4 (7.1; 18.3)10.0 (6.8; 15.9)NS
MIP-1α (pg/ml)82.6 (54.6; 132.7)61.2 (44.1; 107.4)0.008
MCP-1 (pg/ml)291.0 (202.2; 381.9)303.3 (213.8; 415.6)NS
IP-10 (pg/ml)419.8 (309.9; 543.4)299.4 (216.9; 401.6)<0.0001
RANTES (ng/ml)76.9 ± 38.2100.3 ± 44.7<0.0001
  • Data are means ± SD or medians (25th percentile; 75th percentile).