Table 4

Systemic immune mediator levels stratified by ulcer grade (University of Texas classification)

Immune mediatorUT grade 1UT grade 2UT grade 3
n326174
hs-CRP (mg/l)5.2 (2.3; 19.4)11.1 (3.7; 30.7)21.0 (7.9; 61.6)*
Fibrinogen (g/l)4.8 ± 1.35.3 ± 1.76.0 ± 1.6*
IL-6 (pg/ml)7.9 (3.4; 19.1)10.5 (6.9; 25.6)19.8 (8.9; 48.6)
MIF (ng/ml)7.9 (5.8; 10.9)7.0 (5.3; 9.9)8.6 (6.4; 13.4)
IL-18 (pg/ml)131.3 (79.9; 193.8)122.2 (90.7; 169.5)111.3 (85.8; 188.5)
IL-8 (pg/ml)9.4 (6.7; 20.2)11.6 (7.6; 18.5)12.9 (7.0; 18.1)
MIP-1α (pg/ml)83.5 (50.3; 214.2)85.1 (56.2; 127.4)77.6 (54.2; 136.1)
MCP-1 (pg/ml)256.6 (158.8; 321.3)348.4 (220.0; 471.6)284.2 (206.8; 367.9)
IP-10 (pg/ml)431.6 (320.0; 558.5)427.2 (344.9; 517.5)353.2 (275.0; 543.6)
RANTES (ng/ml)75.3 ± 35.777.7 ± 43.675.7 ± 34.1
  • Data are means ± SD or medians (25th percentile; 75th percentile).

  • *P < 0.01;

  • P < 0.001;

  • P < 0.05, compared with University of Texas (UT) classification grade 1.