Predictors of regression to NGR, isolated IFG, or isolated IGT using ADA criteria in a multivariate model
| HR (95% CI) | P | |
|---|---|---|
| Regression to NGR | ||
| ILS versus placebo | 2.05 (1.66–2.53) | <0.0001 |
| Metformin versus placebo | 1.25 (0.99–1.58) | 0.0601 |
| Younger age | 1.07 (1.02–1.11) | 0.0031 |
| Male versus female sex | 1.17 (0.98–1.40) | 0.0784 |
| Caucasian versus non-Caucasian | 1.00 (0.84–1.19) | 0.9986 |
| Lower fasting plasma glucose | 1.52 (1.36–1.68) | <0.0001 |
| Lower 2-h plasma glucose | 1.24 (1.13–1.35) | <0.0001 |
| Greater insulin sensitivity (l/fasting insulin) | 1.07 (0.99–1.16) | 0.0934 |
| Greater insulin secretion (CIR) | 1.09 (1.01–1.17) | 0.0353 |
| Higher baseline weight | 1.01 (0.92–1.11) | 0.8229 |
| Greater weight loss | 1.34 (1.21–1.49) | <0.0001 |
| Regression to isolated IFG | ||
| ILS versus placebo | 1.20 (0.99–1.46) | 0.0576 |
| Metformin versus placebo | 0.98 (0.81–1.19) | 0.8560 |
| Younger age | 1.03 (0.99–1.07) | 0.1590 |
| Male versus female sex | 1.27 (1.08–1.50) | 0.0037 |
| Caucasian versus non-Caucasian | 1.07 (0.91–1.26) | 0.4088 |
| Higher fasting plasma glucose | 1.29 (1.19–1.40) | <0.0001 |
| Lower 2-h plasma glucose | 1.48 (1.36–1.61) | <0.0001 |
| Greater insulin sensitivity (l/fasting insulin) | 1.09 (1.00–1.18) | 0.0441 |
| Greater insulin secretion (CIR) | 1.05 (0.96–1.15) | 0.2591 |
| Higher baseline weight | 1.03 (0.95–1.13) | 0.4467 |
| Greater weight loss | 0.98 (0.89–1.07) | 0.5962 |
| Regression to isolated IGT | ||
| ILS versus placebo | 1.30 (1.01–1.67) | 0.0397 |
| Metformin versus placebo | 1.50 (1.18–1.91) | 0.0009 |
| Younger age | 1.01 (0.96–1.06) | 0.7587 |
| Female versus male sex | 1.58 (1.25–1.99) | 0.0001 |
| Caucasian versus non-Caucasian | 1.13 (0.93–1.38) | 0.2259 |
| Lower fasting plasma glucose | 1.67 (1.47–1.89) | <0.0001 |
| Higher 2-h plasma glucose | 1.19 (1.08–1.31) | 0.0004 |
| Greater insulin sensitivity (l/fasting insulin) | 1.01 (0.91–1.12) | 0.8854 |
| Greater insulin secretion (CIR) | 1.11 (1.01–1.23) | 0.0257 |
| Higher baseline weight | 0.93 (0.83–1.03) | 0.1733 |
| Greater weight loss | 1.13 (1.00–1.28) | 0.0558 |
HRs for continuous variables are per 1 SD (or per 5 years for age).