Table 3

Association of duration of diabetes to brain tissues volumes and cerebral infarcts: AGES–Reykjavik

Duration of diabetesTotal brain volumeGrey matterWhite matterWMLsSingle infarctMultiple infarcts
Nondiabetic72.3 (ref)45.2 (ref)25.7 (ref)1.3 (ref)1.0 (ref)1.0 (ref)
<1 year73.046.025.41.61.56 (0.79–3.04)0.82 (0.19–3.54)
1–6 years71.745.025.11.51.37 (0.84–2.21)2.70 (1.48–4.91)
7–14 years71.4*44.925.11.51.95 (1.22–2.21)2.25 (1.12–4.52)
≥15 years70.944.325.21.31.10 (0.70–1.72)2.02 (1.15–3.58)
Ptrend<0.001<0.001<0.0010.0480.004<0.001
Undiagnosed diabetes71.344.525.41.41.56 (1.05–2.32)*2.20 (1.24–3.88)
  • Data are adjusted mean percentage (adjusted for age, education, sex, smoking status, myocardial infarction, hypertension, BMI, and physical activity) of total intracranial volume or ORs (95% CI). n = 4,415. Ptrend excludes undiagnosed type 2 diabetes.

  • *P < 0.05;

  • P < 0.01;

  • P < 0.001. ref, referent.