Table 2

Laboratory data during treatment with 20, 40, and 60 mg lisinopril in random order compared with baseline in 48 type 1 diabetic patients with diabetic nephropathy

BaselineLisinopril
20 mg40 mg60 mg
24-h systolic blood pressure (mmHg), reduction from baseline10 (6–14)*13 (8–18)*12 (8–17)*
24-h diastolic blood pressure (mmHg), reduction from baseline5 (3–7)*7 (5–10)*7 (5–10)*
Reduction in UAER compared with baseline63 (55–69)*71 (66–76)*70 (64–75)*
eGFR (ml/min per 1.73 m2)75 ± 469 ± 4*68 ± 4*67 ± 4*
A1C (%)8.6 ± 0.18.7 ± 0.28.8 ± 0.28.9 ± 0.1*
Plasma potassium (mmol/l)3.9 ± 0.14.3 ± 0.1*4.4 ± 0.1*4.4 ± 0.1*
U-LFABP reduction compared with baseline43 (15–62)*46 (19–64)*40 (11–60)*
  • Data are means ± SEM or mean difference (95% CI). The Friedman test for several related samples was used followed by a paired-samples t test if significant.

  • *P < 0.05 vs. baseline;

  • P < 0.05 vs. 20 mg.