Table 2

Treatment of painful neuropathy under consideration of comorbidities, side effects, and drug metabolism

DuloxetinePregabalinTricyclicsOpioidsα-Lipoic acid
Depression+n+nn
ObesityNnn
Generalized anxiety disorder++NANANA
Sleep disturbances++++NA
Coronary heart diseasenNnn
Autonomic neuropathyNANA+
Fasting glucose(−)*n(−)*Nn**
Hepatic failuren§§n
Renal failureAdapt dose§§n
Drug interactionsnnn
  • Effect: +, favorable; −, unfavorable; n, neutral; NA, not available;

  • *slight increase possible;

  • **slight decrease possible;

  • §dependent on individual agent.