Table 1

Association between serum IGF-1 levels and diabetes

Serum IGF-1 quartilesP-trend
Highest quartile (>322 ng/ml)Third quartile (248–322 ng/ml)Second quartile (186–247 ng/ml)Lowest quartile (<186 ng/ml)
Whole cohort (n = 5,511)
    Number at risk (cases)1,377 (47)1,378 (78)1,378 (105)1,378 (157)
    Age, sex-adjusted OR (95% CI)1 (referent)1.69 (0.94–3.04)2.71 (1.77–4.17)3.16 (1.81–5.51)<0.0001
    Multivariable-adjusted OR (95% CI)1 (referent)1.33 (0.69–2.53)2.02 (1.28–3.19)2.16 (1.24–3.76)0.002
Age <65 years
    Number at risk (cases)1,316 (30)1,211 (49)1,086 (71)886 (94)
    Age, sex-adjusted OR (95% CI)1 (referent)1.91 (0.91–4.01)3.61 (1.96–6.66)4.54 (1.89–10.93)0.0003
    Multivariable-adjusted OR (95% CI)1 (referent)1.54 (0.70–3.38)2.63 (1.40–4.95)3.05 (1.31–7.08)0.006
Age >65 years
    Number at risk (cases)61 (17)167 (29)292 (34)492 (63)
    Age, sex-adjusted OR (95% CI)1 (referent)0.52 (0.23–1.15)0.42 (0.23–0.78)0.47 (0.24–0.90)0.11
    Multivariable-adjusted OR (95% CI)1 (referent)0.55 (0.20–1.52)0.55 (0.20–1.52)0.51 (0.24–1.06)0.18
  • †Adjusted for age (years), gender, race-ethnicity (non-Hispanic whites, non-Hispanic blacks, Mexican Americans, others), education categories (<high school, high school, >high school), smoking (never, former, current), alcohol intake (never, former, current), BMI (normal, overweight, obese), hypertension (absent, present), estimated glomerular filtration rate (ml/min per 1.73 m2), and total cholesterol (mg/dl). P-interaction for cross-product age × IGF-1 quartile variable was 0.0056.