Table 1

Summary of results for blood glucose and CGM data

Treatment arm −30Treatment arm −15Treatment arm 0Overall P value (repeated-measures ANOVA)*
Blood glucose–derived outcomes
    AUC (mmol/l/min)1.89 ± 0.720.41 ± 0.512.11 ± 0.660.043
    Maximum glucose excursion (mmol/l)6.48 ± 0.764.77 ± 0.526.93 ± 0.760.038
    Peak glucose level (mmol/l)11.74 ± 0.809.26 ± 0.7212.29 ± 0.930.003
    Time spent in euglycemia (min)182.5 ± 28.2224.5 ± 25.090.5 ± 23.20.000
    Hypoglycemic events (no. of measurements)§6 of 2207 of 2204 of 2200.901
CGM–derived outcomes
    AUC (mmol/l/min)2.32 ± 0.591.10 ± 0.111.89 ± 0.340.088
    Maximum glucose (mmol/l)11.48 ± 1.0810.11 ± 0.5911.31 ± 0.820.174
    Maximum glucose excursion (mmol/l)5.24 ± 1.014.37 ± 0.645.41 ± 0.670.537
  • Data are means ± SEM.

  • *Significance between treatment arms when repeated-measures ANOVA indicated an overall significant difference among treatment arms is given in results.

  • †Results are significantly different among groups.

  • ‡Defined as blood glucose values between 3.5 and 10 mmol/l.

  • §Defined as blood glucose values <3.5 mmol/l.