Table 2

Associations of measures of obesity with the prevalence of adenoma and cancer in the colorectum

Colorectal adenomaColorectal cancer
1 (low)23 (high)Ptrend1 (low)23 (high)Ptrend
n8622
Total fat area (cm2)*<214214–288>288<197197–287>287
    No. of case subjects/control subjects33/8522/8631/874/218/2210/23
    Crude OR (95% CI)†10.63 (0.32–1.23)0.87 (0.43–1.74)>0.212.04 (0.52–7.96)2.44 (0.63–9.44)>0.2
    Multivariable OR (95% CI)‡10.64 (0.32–1.27)0.87 (0.43–1.76)>0.212.26 (0.52–9.82)2.76 (0.64–11.87)0.19
Visceral fat area (cm2)*<103103–142>142<9292–129>129
    No. of case subjects/control subjects29/8527/8630/873/216/2213/23
    Crude OR (95% CI)†10.90 (0.44–1.85)1.02 (0.46–2.24)>0.211.88 (0.42–8.35)4.87 (1.11–21.42)0.03
    Multivariable OR (95% CI)‡10.86 (0.41–1.78)0.99 (0.45–2.20)>0.212.17 (0.45–10.46)5.92 (1.22–28.65)0.02
    Multivariable OR (95% CI)§10.89 (0.41–1.97)1.08 (0.42–2.81)>0.212.09 (0.41–10.70)8.42 (0.80–88.56)0.08
Subcutaneous fat area (cm2)*<106106–139>139<101101–145>145
    No. of case subjects/control subjects30/8531/8625/877/217/228/23
    Crude OR (95% CI)†11.0 (0.55–1.83)0.78 (0.40–1.52)>0.210.96 (0.26–3.46)1.04 (0.30–3.66)>0.2
    Multivariable OR (95% CI)‡11.01 (0.55–1.87)0.82 (0.41–1.61)>0.211.17 (0.30–4.51)1.08 (0.29–4.00)>0.2
Waist circumference (cm)*<8282–89>89<8080–88>88
    No. of case subjects/control subjects24/8332/8730/886/214/2212/23
    Crude OR (95% CI)†11.28 (0.69–2.38)1.22 (0.61–2.42)>0.210.70 (0.18–2.78)2.01 (0.58–6.95)>0.2
    Multivariable OR (95% CI)‡11.37 (0.73–2.55)1.18 (0.59–2.35)>0.210.75 (0.18–3.13)2.03 (0.57–7.25)>0.2
BMI (kg/m2)<22.522.5–24.8>24.8<22.222.2–24.8>24.8
    No. of case subjects/control subjects29/8429/8528/893/208/2311/23
    Crude OR (95% CI)†10.98 (0.53–1.83)0.89 (0.46–1.73)>0.212.32 (0.56–9.68)3.65 (0.81–16.44)>0.2
    Multivariable OR (95% CI)‡10.99 (0.52–1.86)0.90 (0.46–1.77)>0.213.00 (0.61–14.86)4.38 (0.82–23.25)0.09
  • *Measured by abdominal CT at the umbilical level in supine position.

  • †Crude.

  • ‡Adjusted for smoking and alcohol drinking.

  • §Additionally adjusted for BMI.