Table 3

Associations of glucose, insulin, and HOMA-IR with the prevalence of adenoma and cancer in the colorectum

Colorectal adenomaColorectal cancer
1 (low)23 (high)Ptrend1 (low)23 (high)Ptrend
n8622
Fasting glucose (mg/dl)<100100–108>108<9999–108>108
    No. of case subjects/control subjects32/7424/9330/914/216/2212/23
    Crude OR (95% CI)*10.57 (0.30–1.08)0.73 (0.39–1.36)>0.211.69 (0.36–7.96)3.12 (0.76–12.74)0.09
    Multivariable OR (95% CI)†10.62 (0.32–1.19)0.76 (0.40–1.42)>0.211.76 (0.35–8.69)4.40 (0.99–19.59)0.04
    Multivariable OR (95% CI)‡10.62 (0.32–1.20)0.76 (0.41–1.44)>0.212.17 (0.41–11.50)4.07 (0.86–19.37)0.07
Fasting insulin (μU/dl)<4.74.7–7.4>7.4<55–7.8>7.8
    No. of case subjects/control subjects29/8529/8328/905/218/228/23
    Crude OR (95% CI)*11.02 (0.57–1.85)0.91 (0.50–1.66)>0.211.55 (0.45–5.32)1.38 (0.40–4.76)>0.2
    Multivariable OR (95% CI)†11.14 (0.61–2.12)1.08 (0.58–2.03)>0.211.65 (0.38–7.28)1.84 (0.47–7.15)>0.2
    Multivariable OR (95% CI)‡11.15 (0.62–2.15)1.15 (0.57–2.31)>0.211.88 (0.39–9.03)1.29 (0.28–5.84)>0.2
HOMA-IR<1.21.2–2.05>2.051.331.33–2.04>2.04
    No. of case subjects/control subjects31/8530/8625/874/218/229/23
    Crude OR (95% CI)*10.95 (0.53–1.72)0.79 (0.43–1.45)>0.211.85 (0.52–6.62)1.89 (0.51–6.94)>0.2
    Multivariable OR (95% CI)†11.08 (0.58–2.00)0.89 (0.47–1.68)>0.212.60 (0.62–10.97)3.10 (0.71–13.54)0.15
    Multivariable OR (95% CI)‡11.08 (0.58–2.03)0.91 (0.45–1.83)>0.212.63 (0.60–11.41)2.20 (0.45–10.81)>0.2
  • *Crude.

  • †Adjusted for smoking and alcohol drinking.

  • ‡Additionally adjusted for BMI.