Table 4

Indicators of pregnancy preparation and pregnancy outcomes during the 2006–2009 regional prepregnancy care program compared with during 1999–2004

1999–20042006–2009P value
Type of diabetes1
    Type 1443408<0.0001
    Type 2162 (26.8)274 (40.2)
Pregnancy loss <20/4060/613 (9.8)125/686 (18.5)<0.0001
Preconception counselling2200/535 (32.5)245/562 (43.6)0.04
    Type 1 diabetes153/389 (40.5)178/337 (52.8)
    Type 2 diabetes42/146 (28.7)67/225 (29.8)
Folic acid preconception174/535 (32.5)229/562 (40.7)0.006
    Type 1 diabetes142/389 (36.4)155/337 (46.0)
    Type 2 diabetes32/146 (21.9)74/225 (32.9)
Metformin
    Type 2 diabetes51/146 (35.2)123/225 (54.7)0.0003
Pregnancy outcome2
Congenital malformation39/535 (7.3)24/562 (4.3)0.04
    Type 117/389 (4.4)14/337 (4.2)1.0(P = 0.05 for interaction)
    Type 218/146 (12.3)10/225 (4.4)0.009
Perinatal mortality20/535 (3.7)10/562 (1.8)0.07
    Type 111/389 (2.8)8/337 (2.4)0.9(P = 0.03 for interaction)
    Type 29/146 (6.2)2/225 (0.9)0.009
Serious adverse outcome49/535 (9.2)34/562 (6.0)0.07
    Type 125/389 (6.4)22/337 (6.5)0.9(P = 0.007 interaction)
    Type 224/146 (16.4)12/225 (5.3)0.0008
  • Data in parentheses are percentages.

  • 1Includes all registered pregnancies in women with type 1 and type 2 diabetes during the 2 study periods.

  • 2For direct comparison with the 1999–2004 study, we have excluded all pregnancies that resulted in miscarriage at <20 weeks' gestation and all terminations for indications other than congenital malformation.