Table 4

Adjusted odds ratios for CKD stages 1–2 and CKD stages 3–5 among KEEP female participants, stratified by age, race, and BMI

ConditionGDMP valueOvert diabetesP valueNo diabetes
CKD stages 1–2 vs. no CKD
    Age*
        <50 years (n = 12,326)1.72 (1.17–2.53)0.0061.69 (1.46–1.95)<0.00011.00 (referent)
        ≥50 years (n = 19,255)1.33 (0.87–2.04)0.21.74 (1.57–1.93)<0.00011.00 (referent)
    Race
        White (n = 15,066)1.12 (0.68–1.84)0.71.45 (1.28–1.65)<0.00011.00 (referent)
        African American (n = 10,945)2.32 (1.50–3.60)0.00021.92 (1.68–2.19)<0.00011.00 (referent)
        Other (n = 5,570)1.35 (0.75–2.42)0.31.83 (1.52–2.21)<0.00011.00 (referent)
    BMI
        <30 kg/m2 (n = 16,964)1.25 (0.82–1.89)0.31.54 (1.36–1.74)<0.00011.00 (referent)
        ≥30 kg/m2 (n = 14,617)1.93 (1.30–2.86)0.0011.89 (1.69–2.11)<0.00011.00 (referent)
    Hypertension§
        No. (n = 16,964)1.24 (0.82–1.88)0.31.60 (1.41–1.81)<0.00011.00 (referent)
        Yes (n = 14,617)1.91 (1.29–2.84)0.0011.86 (1.66–2.08)<0.00011.00 (referent)
CKD stages 3–5 vs. no CKD
    Age*
        <50 years (n = 11,796)0.66 (0.31–1.42)0.31.10 (0.90–1.36)0.41.00 (referent)
        ≥50 years (n = 23,037)0.97 (0.72–1.30)0.81.32 (1.24–1.41)<0.00011.00 (referent)
    Race
        White (n = 17,942)0.83 (0.58–1.19)0.31.07 (0.98–1.16)0.11.00 (referent)
        African American (11,187)1.66 (0.96–2.88)0.071.43 (1.26–1.62)<0.00011.00 (referent)
        Other (n = 5,704)0.64 (0.29–1.43)0.31.39 (1.16–1.66)0.00031.00 (referent)
    BMI
        <30 kg/m2 (n = 18,774)1.01 (0.70–1.44)1.01.18 (1.07–1.29)0.00061.00 (referent)
        ≥30 kg/m2 (n = 16,059)0.89 (0.56–1.39)0.61.25 (1.14–1.36)<0.00011.00 (referent)
    Hypertension§
        No (n = 18,774)0.99 (0.69–1.4)0.91.19 (1.09–1.31)0.00021.00 (referent)
        Yes (n = 16,059)0.87 (0.56–1.38)0.61.22 (1.12–1.33)<0.00011.00 (referent)
  • Data are ORs (95% CI).

  • *Adjusted for race, BMI, current smoking, alcohol use, hypertension, dyslipidemia, and family history of kidney disease.

  • †Adjusted for age, BMI, current smoking, alcohol use, hypertension, dyslipidemia, and family history of kidney disease.

  • ‡Adjusted for age, race, current smoking, alcohol use, hypertension, dyslipidemia, and family history of kidney disease.

  • §Adjusted for age, race, BMI, current smoking, alcohol use, dyslipidemia, and family history of kidney disease.