Table 3

Multivariable-adjusted associations of total magnesium intake (quintiles) with inflammatory markers and HOMA-IR

Quintiles of total magnesium intakePtrend
1 (lowest)2345 (highest)
hs-CRP (n = 4,157)
    Median (mg/l)1.601.371.271.000.86
    Model 10−0.071 (−0.153 to 0.012)−0.008 (−0.093 to 0.077)−0.151 (−0.245 to −0.057)−0.270 (−0.368 to −0.172)<0.01
    Model 20−0.069 (−0.149 to 0.012)0.012 (−0.071 to 0.095)−0.095 (−0.186 to −0.004)−0.190 (−0.286 to −0.094)<0.01
    Model 30−0.058 (−0.140 to 0.024)0.028 (−0.057 to 0.114)−0.071 (−0.166 to 0.024)−0.160 (−0.262 to −0.058)<0.01
IL-6 (n = 3,254)
    Median (mg/l)2.261.961.661.541.39
    Model 10−0.097 (−0.185 to −0.009)−0.154 (−0.245 to −0.062)−0.201 (−0.296 to −0.105)−0.284 (−0.383 to −0.186)<0.01
    Model 20−0.088 (−0.174 to −0.002)−0.134 (−0.223 to −0.044)−0.141 (−0.236 to −0.045)−0.217 (−0.317 to −0.118)<0.01
    Model 30−0.082 (−0.169 to 0.005)−0.121 (−0.214 to −0.029)−0.125 (−0.225 to −0.025)−0.200 (−0.306 to −0.094)<0.01
Fibrinogen (n = 4,325)
    Median (mg/l)314319319316306
    Model 10−0.010 (−0.023 to 0.004)−0.003 (−0.018 to 0.011)−0.018 (−0.033 to −0.002)−0.038 (−0.055 to −0.021)<0.01
    Model 20−0.007 (−0.020 to 0.007)0.005 (−0.009 to 0.019)−0.003 (−0.018 to 0.012)−0.015 (−0.032 to 0.002)0.08
    Model 30−0.007 (−0.021 to 0.006)0.003 (−0.012 to 0.017)−0.006 (−0.022 to 0.010)−0.020 (−0.038 to −0.002)0.03
HOMA-IR (n = 4,239)
    Median (mg/l)2.662.632.502.362.11
    Model 10−0.046 (−0.081 to −0.012)−0.040 (−0.077 to −0.003)−0.085 (−0.123 to −0.047)−0.153 (−0.195 to −0.112)<0.01
    Model 20−0.045 (−0.077 to −0.013)−0.036 (−0.070 to −0.002)−0.068 (−0.103 to −0.033)−0.122 (−0.160 to −0.084)<0.01
    Model 30−0.046 (−0.078 to −0.013)−0.036 (−0.071 to −0.000)−0.065 (−0.102 to −0.029)−0.117 (−0.157 to −0.077)<0.01
  • Data are β coefficients (95% CIs) unless otherwise indicated. A logarithmic transformation was used to improve the normality of distribution for dependent variables. Generalized estimating equations were used for repeated measurements of hs-CRP, fibrinogen, and HOMA-IR, and a general linear regression model was used for IL-6. The median magnesium level in each quintile was created for the trend tests. The adjusted covariates in the models were the same as those listed in Table 2.