Table 2

Familial RRs for type 2 diabetes in offspring according to the number of probands

Proband (n families, median age at hospitalization of offspring)MenWomenAll
OSIR (95% CI)OSIR (95% CI)Person-yearsOSIR (95% CI)
1. Parent, no age limitation (4,356, 51 years)3,5451.99 (1.93–2.06)2,1172.11 (2.02–2.20)4,923,3225,6622.03 (1.98–2.09)
2. Parent <76 years (2,198, 50 years)2,3532.30 (2.21–2.40)1,4262.56 (2.43–2.69)2,751,5453,7792.39 (2.32–2.47)
3. Two parents <76 years (109, 49 years)984.99 (4.05–6.08)656.02 (4.65–7.68)51,2411635.35 (4.56–6.24)
4. Singleton sibling (671, 52 years)1,0332.73 (1.81–4.10)6502.85 (1.86–4.35)865,4751,6832.77 (1.87–4.11)
5. Two singleton siblings (30, 52 years)5731.58 (16.91–57.88)3351.87 (25.23–103.12)2,9769036.86 (20.96–64.10)
6. Three or more singleton siblings (3, 47 years)622.78 (5.80–70.58)669.44 (17.67–215.18)4321234.31 (12.47–85.01)
7. Singleton sibling and parent <76 years (117, 50 years)1734.46 (3.82–5.18)1114.80 (3.95–5.79)99,7332844.59 (4.07–5.16)
8. Singleton sibling and two parents <76 years (7, 50 years)85.10 (2.18–10.10)1010.33 (4.92–19.07)3,884187.10 (4.20–11.24)
9. Two or more singleton sibling and parent <76 years (9, 53 years)1828.24 (16.70–44.71)1153.14 (26.38–95.41)8912934.34 (22.98–49.37)
10. Spouse, no age limitation3,2961.31 (1.26–1.35)3,1781.33 (1.29–1.38)3,490,1786,4741.32 (1.29–1.35)
  • O, observed number of cases.