Table 3

Fully adjusted HRs (95% CI) for incident diabetes in relation to body shape history over the life course, from birth to middle age, in the E3N cohort (1990–2007)

BMI <25 kg/m2 at baselineBMI ≥25 kg/m2 at baseline
Cases/total person-yearsHR (95% CI)*Cases/total person-yearsHR (95% CI)*
Low birth weight
    Silhouette 1 at 8 years71/63,0631.78 (1.31–2.43)22/9,2324.83 (3.62–6.45)
    Silhouette 2 at 8 years426/13,1271.35 (0.72–2.53)174/1,9683.12 (1.77–5.50)
    Silhouette ≥3 at 8 years29/11,0051.48 (0.79–2.77)22/3,3683.11 (1.99–4.87)
Medium birth weight
    Silhouette 1 at 8 years71/428,3481.64 (1.32–2.05)25/60,0753.45 (2.75–4.33)
    Silhouette 2 at 8 years297/169,6331208/29,0372.80 (2.16–3.61)
    Silhouette ≥3 at 8 years13/171,2610.72 (0.53–0.97)42/43,2032.05 (1.59–2.63)
Large birth weight
    Silhouette 1 at 8 years29/35,8251.34 (0.88–2.03)15/6,2271.43 (0.89–2.30)
    Silhouette 2 at 8 years138/19,0440.67 (0.33–1.38)150/4,1552.22 (1.41–3.52)
    Silhouette ≥3 at 8 years8/34,8960.63 (0.36–1.10)31/11,9331.77 (1.25–2.50)
  • *Adjusted for physical activity (<34/34–47/47–62/≥2 MET-h/week), education (≤9/10–11/12–14/15–16/≥17 years), prematurity (no/yes), family history of diabetes (none/only one parent/both parents), smoking (never/former/current smoker, time-dependent variable), high cholesterol level (no/yes), hypertension (no/yes, time-dependent variable), menopausal status (no/yes, time-dependent variable), hormone replacement therapy (never/ever, time-dependent variable), oral contraceptive pills (never/ever), parity and age at first child (nulliparous/first child at <30 years, 1–2 children/first child at <30 years, 3+ children/first child at ≥30 years or more), age at menarche (≤12/13/≥14 years old), and adult BMI as a time-dependent variable, according to birth cohort (1,925–1,930/1,930–1,935/1,935–1,940/1,940–1,945/1,945–1,950).