Table 2

Blood pressure, arterial stiffness, and endothelial function responses to a DRI in type 1 diabetes

ParameterBefore DRIAfter DRI
EuglycemiaHyperglycemiaEuglycemiaHyperglycemia
Heart rate (bpm)63 ± 261 ± 364 ± 362 ± 2
Blood pressure
    Peripheral SBP (mmHg)120 ± 4123 ± 4107 ± 3*111 ± 4†
    Peripheral DBP (mmHg)70 ± 272 ± 262 ± 3*68 ± 3†
Renal hemodynamic function
    ERPF558 ± 27606 ± 29665 ± 24*704 ± 35†
    GFR105 ± 3117 ± 5114 ± 3*124 ± 2†
    Filtration fraction0.19 ± 0.010.20 ± 0.0010.18 ± 0.010.18 ± 0.01
    RBF914 ± 58984 ± 651,049 ± 59*1,102 ± 76†
    Renal vascular resistance0.082 ± 0.0130.086 ± 0.0100.080 ± 0.0130.078 ± 0.007
Applanation tonometry
    Central SBP (mmHg)104 ± 3109 ± 497 ± 3*103 ± 3†
    Augmentation index (%)21.7 ± 16.622.0 ± 5.016.6 ± 4.8*18.7 ± 4.6
    Aortic PWV (m/s)7.4 ± 0.47.8 ± 0.66.7 ± 0.46.8 ± 0.5†
Endothelial function
    Flow (% change)74.58 ± 5.6381.01 ± 7.3275.54 ± 9.6969.59 ± 8.19
    FMD (% change)1.92 ± 1.131.86 ± 0.985.55 ± 0.81*5.63 ± 0.62†
    FMD/flow0.030 ± 0.0170.036 ± 0.0150.084 ± 0.015*0.094 ± 0.016†
    GTN (% change)9.52 ± 2.0111.22 ± 1.3614.22 ± 1.49*15.85 ± 1.46†
  • Data are means ± SEM.

  • *P < 0.05 vs. pre-DRI parameter during clamped euglycemia.

  • P < 0.05 vs. pre-DRI parameter during clamped hyperglycemia. DBP, diastolic blood pressure; flow, % change in instantaneous flow; SBP, systolic blood pressure; PWV, pulse wave velocity.