Table 2

Predictors of preeclampsia in women with type 1 diabetes: univariate and multivariate logistic regression analyses

Univariate logistic regressionMultivariate logistic regression
OR (95% CI)POR (95% CI)P
Age (years)1.0 (0.9–1.0)0.07
BMI (kg/m2)1.1 (1.0–1.1)0.0031.04 (1.0–1.1)0.17
Duration of diabetes (years)1.03 (1.01–1.05)0.0031.01 (1.0–1.04)0.21
Nulliparity2.6 (1.7–4.1)<0.0013.1 (1.9–5.3)<0.001
Prepregnancy insulin dose (IU/day)1.02 (1.01–1.03)<0.0011.01 (1.00–1.03)0.14
Blood pressure ≥140/90 mmHg at first visit5.8 (1.4–23.6)0.0111.0 (1.0–1.02)0.91
Proliferative retinopathy1.9 (0.9–4.4)0.30
First-trimester A1C (%)*1.2 (1.0–1.3)0.016
Third-trimester A1C (%)1.2 (1.1–1.4)0.0081.3 (1.1–1.5)0.010
Microalbuminuria5.0 (3.0–8.1)<0.0014.0 (2.2–7.2)<0.001
  • *First-trimester A1C was not a significant predictor in a separate multivariate model without third-trimester A1C (OR 1.2 [95% CI 0.9–1.4], P = 0.07). ORs of microalbuminuria, nulliparity, and prepregnancy insulin dose did not change significantly in this model.