Table 1

Threshold values for diagnosis of GDM or overt diabetes in pregnancy

To diagnose GDM and cumulative proportion of HAPO cohort equaling or exceeding those thresholds
Glucose measureGlucose concentration threshold*Above threshold (%)
mmol/lmg/dlCumulative
FPG5.1928.3
1-h plasma glucose10.018014.0
2-h plasma glucose8.515316.1†
To diagnose overt diabetes in pregnancy
Measure of glycemiaConsensus threshold
FPG‡≥7.0 mmol/l (126 mg/dl)
A1C‡≥6.5% (DCCT/UKPDS standardized)
Random plasma glucose≥11.1 mmol/l (200 mg/dl) + confirmation§
  • *One or more of these values from a 75-g OGTT must be equaled or exceeded for the diagnosis of GDM.

  • †In addition, 1.7% of participants in the initial cohort were unblinded because of FPG >5.8 mmol/l (105 mg/dl) or 2-h OGTT values >11.1 mmol/l (200 mg/dl), bringing the total to 17.8%.

  • ‡One of these must be met to identify the patient as having overt diabetes in pregnancy.

  • §If a random plasma glucose is the initial measure, the tentative diagnosis of overt diabetes in pregnancy should be confirmed by FPG or A1C using a DCCT/UKPDS-standardized assay.