Table 3

Multivariate associations between cortisol and late-life cognition and estimated cognitive change*

UnadjustedModel 1Model 2Model 3Model 4
+Sex and age+MHVS+Other covariates+Interactions
β§PβPβPβPβP
MR−0.040.28−0.030.46−0.040.18−0.050.08NSI
LNS−0.060.07−0.050.13−0.070.04−0.070.02−0.440.002
VFT0.040.270.040.210.030.360.020.51NSI
DST−0.060.07−0.050.13−0.070.03−0.060.04NSI
lnTMT0.050.130.040.240.050.090.050.12NSI
FACES−0.050.13−0.050.08−0.060.09−0.060.07NSI
LM0.040.200.050.160.040.270.050.13NSI
g−0.050.20−0.030.37−0.050.09−0.050.06−0.300.015
  • *Cognitive test scores adjusted for MHVS.

  • †Other covariates = HADS score, duration of diabetes, A1C, total cholesterol, BMI, hypertension, smoking, alcohol intake, myocardial infarction, angina, stroke, ABI, and level of education.

  • ‡Interactions between plasma cortisol and covariates were tested for all models. Significant interactions were included in the LNS model (cortisol by ABI: β = 0.572, P = 0.002; cortisol by alcohol intake: β = −0.436, P = 0.001) and the g model (cortisol by ABI: β = 0.331, P = 0.038).

  • §Standardized β. NSI, no significant interactions.