Table 2

RR of type 2 diabetes according to family history of diabetes adjusted for various measures of body fatness

No family historyFamily history
Adjustment for adolescent BMI (1984–2004)*
    Model 11 (referent)2.14 (2.01–2.27)
    Model 1 and BMI1 (referent)1.96 (1.85–2.09)
    Model 1 and BMI and BMI at age 18 years1 (referent)1.99 (1.87–2.11)
    Model 1 and BMI at age 18 years and weight change1 (referent)2.00 (1.88–2.12)
Adjustment for body fat distribution (1986–2004)
    Model 11 (referent)2.18 (2.03–2.34)
    Model 1 and BMI1 (referent)1.99 (1.85–2.14)
    Model 1 and waist and hip circumference1 (referent)2.01 (1.87–2.16)
    Model 1 and BMI and waist and hip circumference1 (referent)1.97 (1.83–2.12)
  • Family history of diabetes denotes diabetes in ≥1 first-degree family members. Weight change denotes weight change since age 18 years. All anthropometric variables were modeled as continuous variables: BMI (weight in kilograms divided by the square of height in meters), waist circumference (centimeters), hip circumference (centimeters), and weight change (kilograms).

  • *Restricted to participants with complete data on BMI at age 18 years (4,822 diabetes events during 1,295,965 person-years of follow-up).

  • †Adjusted for age, race, SES, and lifestyle as described in the footnotes to Table 1.

  • ‡Restricted to participants with complete data on waist and hip circumference with follow-up starting in 1986 when data on waist and hip circumference were first collected (3,201 diabetes events during 834,231 person-years of follow-up).