Table 3

Kinetic indices for apoB-100 before and after intervention in the weight loss and ezetimibe plus weight loss groups

Weight lossEzetimibe plus weight loss
022 weeks022 weeks
n1015
VLDL–apoB-100
    Concentration (mg/l)142 ± 123123 ± 19134 ± 12109 ± 11
    Fractional catabolic rate (pools/day)4.8 ± 1.13.8 ± 0.43.9 ± 0.44.2 ± 0.3
    Production rate (mg/kg FFM/day)41 ± 529 ± 738 ± 332 ± 4
IDL–apoB-100
    Concentration (mg/l)76 ± 1074 ± 1282 ± 965 ± 9§
    Fractional catabolic rate (pools/day)3.9 ± 0.73.6 ± 0.33.5 ± 0.44.5 ± 0.5§
    Production rate (mg/kg FFM/day)20 ± 318 ± 220 ± 218 ± 2
LDL–apoB-100
    Concentration (mg/l)957 ± 61885 ± 36952 ± 76774 ± 62*
    Fractional catabolic rate (pools/day)0.35 ± 0.030.34 ± 0.030.31 ± 0.020.39 ± 0.03*
    Production rate (mg/kg FFM/day)26 ± 322 ± 222 ± 121 ± 2
  • Data are means ± SEM.

  • *P <0.01, value significantly different from baseline value.

  • P < 0.05.

  • P< 0.05, value significantly different using general linear modeling after adjustment for relative changes in the weight loss group.

  • §P = 0.06, value different from baseline value.