Table 2

Meal challenge and hyperglycemic clamp results

LS Mean ± SEMP
EXEEXE+ROSIROSIP value EXE vs. EXE+ROSIP value EXE vs. ROSIP value EXE+ROSI vs. ROSI
Meal challenge
n333434
Glucose AUC (mmol-min/l)
    Baseline1,783 ± 601,800 ± 601,742 ± 60
    End point1,215 ± 51*1,140 ± 50*1,349 ± 51*
    Change−560 ± 51−635 ± 50−426 ± 510.2960.0650.004
Insulin AUC (μIU-min/ml)
    Baseline6,116 ± 7235,203 ± 7126,797 ± 734
    End point5,024 ± 339*4,152 ± 336*4,050 ± 346*
    Change−999 ± 339−1,871 ± 336−1,973 ± 3460.0710.0470.833
C-peptide AUC (nmol-min/l)
    Baseline333 ± 18330 ± 18342 ± 18
    End point310 ± 13277 ± 13*282 ± 13*
    Change−24 ± 13−58 ± 13−53 ± 130.0670.1180.805
I/G Index (AUC) (μIU-min/ml)/(mmol-min/l)
    Baseline3.64 ± 0.483.05 ± 0.474.10 ± 0.48
    20 weeks4.41 ± 0.27*3.61 ± 0.273.06 ± 0.28
    Change0.82 ± 0.270.03 ± 0.27−0.53 ± 0.280.0410.0010.160
Matsuda index
    Baseline4.0 ± 0.64.4 ± 0.63.4 ± 0.6
    20 weeks5.6 ± 0.8*8.4 ± 0.8*7.1 ± 0.8*
    Change1.6 ± 0.84.4 ± 0.83.1 ± 0.80.0150.2050.258
I/G (AUC) × Matsuda
    Baseline10.8 ± 1.08.8 ± 1.010.9 ± 1.0
    20 weeks17.1 ± 1.4*20.4 ± 1.4*18.4 ± 1.5*
    Change7.0 ± 1.410.3 ± 1.48.2 ± 1.50.1110.5500.325
Hyperglycemic Clamp (μIU-min/ml)
    n161816
ASI-iAUC
    Baseline643 ± 107686 ± 104786 ± 114
    20 weeks1,449 ± 187*896 ± 182602 ± 200
    Change747 ± 187195 ± 182−100 ± 2000.0390.0040.282
1st phase iAUC (0–10 min)
    Baseline6 ± 14−10 ± 1423 ± 15
    20 weeks105 ± 24*59 ± 24*17 ± 26
    Change99 ± 2454 ± 2512 ± 260.1950.0180.252
2nd phase iAUC (10–70 min)
    Baseline937 ± 291740 ± 2821,125 ± 309
    20 weeks5,436 ± 833*3,422 ± 813*487 ± 891
    Change4,513 ± 8332,500 ± 813−435 ± 8910.09<0.0010.019
1st and 2nd phase iAUC (0–70 min)
    Baseline955 ± 306742 ± 2971,162 ± 326
    20 weeks5,611 ± 862*3,527 ± 842*503 ± 922
    Change4,671 ± 8622,587 ± 842−437 ± 9220.09<0.0010.02
  • Data are LS means ± SEM.

  • *P <0.05 from baseline. Matsuda Index = Embedded Image, where FPG and FPI = fasting plasma glucose and insulin and G̅ = average glucose during the meal challenge.