Table 3

A1C change across increasing categories of baseline periodontal disease (of sites with attachment loss ≥5 mm): SHIP, 1997–2006

ModelALI (0 ± 0%)*ALII (4 ± 2%)*ALIII (18 ± 7%)*ALIV (62 ± 21%)*EdentulousP value
n1,122488463479241
1−0.035 ± 0.0170.017 ± 0.0260.097 ± 0.0250.162 ± 0.0290.225 ± 0.047<0.001
20.017 ± 0.0180.022 ± 0.0260.071 ± 0.0260.109 ± 0.0300.130 ± 0.0510.009
30.020 ± 0.0180.023 ± 0.0260.064 ± 0.0260.105 ± 0.0300.136 ± 0.0500.013
40.023 ± 0.0180.023 ± 0.0270.065 ± 0.0260.106 ± 0.0300.124 ± 0.0520.025
50.020 ± 0.0170.020 ± 0.0240.080 ± 0.0220.090 ± 0.0280.143 ± 0.0480.011
60.032 ± 0.0390.029 ± 0.0350.043 ± 0.0400.107 ± 0.0420.110 ± 0.0730.02
70.024 ± 0.0260.021 ± 0.0310.045 ± 0.0290.117 ± 0.0400.100 ± 0.052<0.05
80.012 ± 0.0180.019 ± 0.0230.071 ± 0.0260.098 ± 0.0260.101 ± 0.0430.013
90.012 ± 0.0170.014 ± 0.0220.061 ± 0.0240.088 ± 0.0260.071 ± 0.0410.038
10−0.022 ± 0.015−0.012 ± 0.0190.039 ± 0.0220.068 ± 0.0220.031 ± 0.0340.008
  • Data are means ± SEM. Model 1: unadjusted. Model 2: adjusted for age, sex, and region. Model 3: model 2 + smoking and WHR. Model 4: model 3 + education, systolic blood pressure, triglycerides, and physical activity (n = 10 participants excluded because of missing triglyceride data). Model 5: model 4 + natural log of baseline A1C. Model 6: model 4 + hs-CRP, WBC count, fibrinogen, and corticosteroid use (n = 146 participants excluded because of missing data on hs-CRP, WBC count, or fibrinogen; additional n = 78 excluded due to hs-CRP >10 mg/l). Model 7: model 6 + family history of diabetes (parent or sibling; n = 408 participants excluded because of uncertain family history) (n = 54 participants reported corticosteroid use). Model 8: model 4 adjustments removing n = 8 participants with A1C change <−3.0 or >3.0. Model 9: model 4 adjustments removing n = 21 participants with A1C change <−2.0 or >2.0. Model 10: model 4 adjustments removing n = 157 participants with A1C change <−1.0 or >1.0.

  • *Category-specific value for adjustment loss ≥5 mm.

  • P value for linear trend across dentate participants. All SEMs and significance levels account for the stratified, clustered sampling design in SHIP.