Table 2

Prevalence of clinical (symptoms and signs) and NCS results suggestive of distal symmetrical polyneuropathy at DCCT baseline, DCCT closeout, and EDIC years 13–14

VariableDCCT baselineDCCT closeoutEDIC years 13–14
Clinical examination
    Symptoms
        INT32 (5)44 (7)*119 (20)
        CONV39 (7)75 (13)172 (30)
    Abnormal sensation
        INT128 (21)147 (25)248 (41)*
        CONV120 (21)206 (36)292 (50)
    Abnormal reflexes
        INT105 (18)135 (23)264 (44)
        CONV93 (16)212 (37)292 (50)
    Clinical neuropathy
        INT57 (10)88 (15)204 (34)
        CONV48 (8)128 (22)240 (41)
Electrophysiology
    Abnormal NCS
        INT185 (31)164 (28)326 (54)
        CONV196 (34)288 (50)401 (69)
Primary outcome
    Confirmed clinical neuropathy
        INT39 (7)52 (9)152 (25)
        CONV31 (5)97 (17)204 (35)
  • Data are n (%).

  • *P < 0.01 former intensive treatment group (INT) vs. former conventional treatment group (CONV).

  • P < 0.001 INT vs. CONV.