Table 3

NCS results at DCCT baseline, DCCT closeout, and EDIC years 13–14

Nerve/attributeDCCT baselineDCCT closeoutEDIC years 13–14
Median motor
    Amplitude (abnormal limit <4.2) (mV)
        INT10.2 (4.5–17.5)10.1 (5.0–16.0)8.8 (4.2–14.8)
        CONV10.0 (4.5–17.0)10.0 (5.0–16.0)8.9 (4.0–14.4)
    Conduction velocity (abnormal limit <49.0) (m/s)
        INT54.0 (46.5–61.2)55.0 (48.0–61.1)51.4 (42.5–58.2)*
        CONV53.8 (46.9–60.3)52.3 (44.2–59.3)51.0 (42.9–57.7)
    F wave latency (abnormal limit >31.8) (ms)
        INT28.0 (24.0–33.0)27.6 (24.1–32.1)29.5 (25.4–35.0)
        CONV28.0 (24.0–32.6)28.8 (24.8–34.0)29.9 (25.6–36.4)
Median sensory
    Amplitude (abnormal limit <10.0) (μV)
        INT19.0 (7.0–47.0)15.0 (5.0–45.0)9.0 (0.0–29.0)
        CONV20.0 (7.0–50.0)14.0 (3.0–40.0)8.0 (0.0–29.0)
    Conduction velocity (abnormal limit <48.0) (m/s)
        INT51.8 (38.2–63.4)51.8 (36.8–62.0)43.8 (25.9–57.9)
        CONV52.1 (39.4–64.0)50.0 (33.0–61.0)43.1 (25.9–56.8)
Peroneal motor
    Amplitude (abnormal limit <2.5) (mV)
        INT5.6 (2.0–10.0)5.8 (2.0–10.0)4.2 (0.3–9.0)
        CONV5.5 (2.0–10.9)5.0 (1.1–10.0)3.5 (0.1–7.6)
    Conduction velocity (abnormal limit <40.0) (m/s)
        INT43.7 (35.5–51.5)45.0 (37.0–52.0)42.1 (30.5–49.3)
        CONV43.8 (35.6–50.9)41.5 (33.0–49.0)40.6 (25.7–47.8)
    F wave latency (abnormal limit >56.0) (ms)
        INT50.4 (41.6–61.6)50.6 (42.0–69.8)53.3 (43.9–74.0)
        CONV50.8 (40.4–62.0)54.5 (42.9–69.8)55.5 (45.1–74.0)
Sural sensory
    Amplitude (abnormal limit <5.0) (μV)
        INT12.0 (0.0–28.0)11.0 (0.0–27.0)7.0 (0.0–18.0)
        CONV13.0 (0.0–30.0)9.0 (0.0–23.0)5.0 (0.0–15.0)
Conduction velocity (abnormal limit <40.0) (m/s)
        INT45.1 (35.0–56.0)45.2 (35.9–56.0)42.4 (29.8–51.9)
        CONV45.2 (34.1–56.0)42.4 (34.6–52.0)40.0 (29.8–50.0)
Overall (test of stochastic ordering)Z = 1.74Z = 7.99Z = 4.60
P = 0.0819P = <0.0001P = <0.0001
  • Data are median (5–95%).

  • *P < 0.05 former intensive treatment group (INT) vs. former conventional treatment group (CONV).

  • P < 0.01 INT vs. CONV.

  • ‡The test of stochastic ordering tests whether the majority of the measures show differences in a single direction, thus favoring one treatment group over the other.