Table 1

Safety parameters in treatment and placebo groups during study follow-up

Parameter1,25(OH)2D3Placebo
Month 0Month 9Month 18Month 0Month 9Month 18
n4718
Calcium (mmol/l)2.4 ± 0.12.4 ± 0.12.4 ± 0.12.5 ± 0.12.4 ± 0.12.4 ± 0.1
Alkaline phosphatase (IU/ml)67 ± 1962 ± 1760 ± 1765 ± 2662 ± 1663 ± 17
Phosphate (mmol/l)1.2 ± 0.21.2 ± 0.21.1 ± 0.21.2 ± 0.21.2 ± 0.21.1 ± 0.2
Creatinine (mg/dl)0.8 ± 0.10.9 ± 0.10.8 ± 0.10.8 ± 0.10.8 ± 0.10.8 ± 0.1
24-h calcium urine excretion (mmol/24 h)6.3 ± 3.26.0 ± 3.86.2 ± 3.36.1 ± 3.25.5 ± 4.05.2 ± 3.1
  • Data are means ± SD.