Table 2

Energy-adjusted phylloquinone and menaquinones intake and risk of type 2 diabetes among 38.094 Dutch men and women

Quartile 1Quartile 2Quartile 3Quartile 4Ptrend valuePer 50 μg
Phylloquinone
    Intake (μg/day)100.1155.7211.4308.1
    Age-, sex-, waist-adjusted1.00.89 (0.73–1.08)0.95 (0.79–1.14)0.89 (0.74–1.07)0.351.00 (0.97–1.03) P = 0.92
    Multivariate adjusted*1.00.89 (0.74–1.09)0.94 (0.78–1.14)0.88 (0.73–1.06)0.260.99 (0.96–1.02) P = 0.65
    Multivariate adjusted1.00.87 (0.71–1.06)0.90 (0.74–1.09)0.81 (0.66–0.99)0.080.98 (0.95–1.02) P = 0.31
Menaquinones
    Intake (μg/day)16.024.532.946.1Per 10 μg
    Age-, sex-, waist-adjusted1.01.03 (0.85–1.25)0.95 (0.78–1.15)0.86 (0.71–1.05)0.070.95 (0.91–1.01) P = 0.060
    Multivariate adjusted*1.01.04 (0.86–1.26)0.97 (0.80–1.17)0.88 (0.73–1.08)0.130.96 (0.91–1.02) P = 0.12
    Multivariate adjusted1.00.99 (0.82–1.21)0.89 (0.72–1.10)0.80 (0.62–1.02)0.040.93 (0.87–1.00) P = 0.038
  • Data are HRs (95% CI).

  • *Adjusted for age, sex, waist circumference, smoking status, physical activity, hypertension, education, alcohol consumption, and total energy intake.

  • †Adjusted for confounders in footnote * and energy-adjusted intake of saturated, polyunsaturated, and monounsaturated fat, protein, fiber, calcium, vitamin C, and vitamin E.