Table 1

Body composition, circulating cardiovascular risk biomarkers and percentage change from baseline

nBaselineEndpointPercentage change from baseline
LS meanBetween-treatment group differenceP
Total fat mass (kg)
    Insulin glargine2829.9 ± 1.628.5 ± 1.9−1% (−7% to +5%)
    Exenatide2927.8 ± 1.425.4 ± 1.6−11% (−18% to −5%)−10% (−16% to −4%)0.003
Total lean mass (kg)
    Insulin glargine2860.1 ± 1.760.6 ± 1.80% (−1% to +2%)
    Exenatide2957.8 ± 2.158.1 ± 2.40% (−2% to +1%)−1% (−3% to +1%)0.480
Trunk fat mass (kg)
    Insulin glargine2817.8 ± 0.916.6 ± 1.1−1% (−8% to +5%)
    Exenatide2916.3 ± 0.814.8 ± 1.0−13% (−18 to −7%)−11% (−18% to −4%)0.002
Body weight (kg)
    Insulin glargine2994.1 ± 2.593.8 ± 2.7−1% (−3% to +1%)
    Exenatide3090.3 ± 2.486.4 ± 2.6−6% (−8% to −3%)−5% (−7% to −2%)0.001
Waist circumference (cm)
    Insulin glargine29106.9 ± 1.9107.4 ± 2.0+1% (−1% to +3%)
    Exenatide30106.1 ± 1.9100.6 ± 2.1−5% (−7% to −3%)−6% (−8% to −4%)<0.001
Leptin (μg/l)
    Insulin glargine297.79 ± 1.298.41 ± 1.53+7% (−11% to +29%)
    Exenatide308.50 ± 1.327.45 ± 1.17−14% (−27% to +2%)−19% (−34% to −1%)0.045
Total adiponectin (ng/ml)
    Insulin glargine294,648 ± 4614,508 ± 436−5% (−13% to +5%)
    Exenatide304,848 ± 4325,314 ± 466+12% (+3% to +21%)+17% (+6% to +30%)0.004
HMW adiponectin (ng/ml)
    Insulin glargine291,277 ± 2211,321 ± 236−0% (−24% to +31%)
    Exenatide301,571 ± 2551,850 ± 273+19% (−6% to +51%)+19% (−12% to +61%)0.253
hs-CRP (mg/l)
    Insulin glargine291.42 ± 0.271.38 ± 0.35−20% (−50% to +27%)
    Exenatide301.81 ± 0.251.30 ± 0.22−61% (−74% to −42%)−52% (−71% to −19%)0.008
IL-6 (pg/ml)
    Insulin glargine291.96 ± 0.212.17 ± 0.20−4% (−26% to +25%)
    Exenatide302.11 ± 0.222.10 ± 0.25−10% (−28% to +14%)−6% (−30% to +26%)0.670
MCP-1 (pg/ml)
    Insulin glargine291.22 ± 0.071.24 ± 0.07−1% (−12% to +11%)
    Exenatide301.18 ± 0.091.21 ± 0.11−4% (−13% to +7%)−2% (−14% to +12%)0.728
Resistin (ng/ml)
    Insulin glargine29330 ± 15329 ± 20−3% (−13% to +7%)
    Exenatide30316 ± 14311 ± 16−0% (−9% to +9%)+3% (−8% to +16%)0.577
Endothelin-1 (ng/ml)
    Insulin glargine292.57 ± 0.182.46 ± 0.19−7% (−11% to −2%)
    Exenatide302.53 ± 0.192.53 ± 0.19−1% (−5% to +3%)+6% (−1% to +12%)0.045
  • Data are means ± SEM (body composition measures) or geometric means ± SEM (cardiovascular biomarkers) and body weight change–adjusted least-squares mean percentage change (95% CI) from baseline. LS, least-squares.