Table 3

Percentage of patients with weight change by category and mean change in glycemic and lipid parameters based on the specified weight change category*

ParameterLost ≥5%Lost 3–4%Lost 1–2%No changeGained 1–2%Gained 3–4%Gained ≥5%P value
Body weight change (%)
    Exenatide32.715.117.39.012.46.66.8NA
    Sitagliptin18.714.020.410.918.09.09.0NA
    Insulin17.09.013.58.015.912.424.2NA
A1C (%)
    Exenatide−0.7−0.5−0.3−0.3−0.3−0.3−0.7<0.0001
    Sitagliptin−0.7−0.5−0.4−0.5−0.6−0.6−1.1<0.0001
    Insulin−0.8−0.5−0.6−0.6−0.7−0.9−1.7<0.0001
FBG (mg/dL)
    Exenatide−16.6−10.3−5.9−1.9−2.4−8.7−11.00.002
    Sitagliptin−19.6−8.3−8.3−8.4−13.1−15.1−23.70.008
    Insulin−18.2−12.7−15.0−18.8−23.7−25.7−43.0<0.0001
SBP (mmHg)
    Exenatide−5.0−3.0−0.90.10.0−0.4−0.3<0.0001
    Sitagliptin−3.9−2.2−1.1−1.20.9−0.92.3<0.0001
    Insulin−5.6−3.3−2.1−1.5−1.6−0.20.6<0.0001
DBP (mmHg)
    Exenatide−2.4−1.1−0.5−0.8−0.3−0.9−0.4<0.0001
    Sitagliptin−1.8−0.6−0.6−0.50.2−0.60.30.0004
    Insulin−2.7−1.9−1.2−1.0−1.2−0.8−0.5<0.0001
Triglycerides (mg/dL)
    Exenatide−43.4−25.2−11.6−6.4−28.0−29.63.50.007
    Sitagliptin−45.6−35.2−17.5−8.1−1.7−7.8−11.80.001
    Insulin−51.4−37.2−36.8−44.4−34.8−49.5−50.30.49
Total cholesterol (mg/dL)
    Exenatide−16.4−9.2−8.8−9.0−8.0−6.6−4.70.0003
    Sitagliptin−14.5−14.8−6.0−5.6−4.7−12.9−13.50.0005
    Insulin−14.2−17.8−12.4−12.5−12.7−11.7−16.60.02
LDL-cholesterol (mg/dL)
    Exenatide−8.1−0.2−1.4−3.1−1.4−2.7−4.00.005
    Sitagliptin−7.3−9.8−4.7−2.2−4.1−8.4−7.90.24
    Insulin−7.7−10.7−8.9−6.7−7.3−6.5−9.50.30
HDL-cholesterol (mg/dL)
    Exenatide−0.9−0.6−0.3−0.3−0.5−0.71.10.06
    Sitagliptin−0.3−1.1−0.6−1.4−0.7−0.4−0.90.63
    Insulin0.1−0.40.20.4−0.8−0.1−0.30.09
  • *Percentages were rounded to whole numbers. Actual ranges were ≥0.5–<0.5% of listed ranges.

  • †Cross-category ANOVA. NA, not applicable.