Table 1

Odds ratios (95% CI) for 9-year incident diabetes, per 1 SD change in waist circumference and weight in IFG: the DESIR study

All IFG participantsBMI <25 kg/m2BMI ≥25 kg/m2
n = 979n = 433n = 546
Odds ratio (95% CI)POdds ratio (95% CI)*POdds ratio (95% CI)P
Univariate
Change in waist circumference1.69 (1.41–2.03)<0.00012.48 (1.73–3.55)<0.00011.48 (1.20–1.84)0.0003
Change in weight1.83 (1.53–2.19)<0.00011.86 (1.35–2.55)<0.00011.85 (1.48–2.32)<0.0001
Model 1
Change in waist circumference1.79 (1.45–2.21)<0.00012.40 (1.63–3.52)<0.00011.66 (1.28–2.16)0.0002
Change in weight1.86 (1.51–2.30)<0.00011.92 (1.32–2.79)0.00061.96 (1.50–2.55)<0.0001
Model 2
Change in waist circumference1.65 (1.30–2.09)<0.00011.82 (1.21–2.75)0.0041.66 (1.22–2.24)0.001
Change in weight1.67 (1.30–2.15)<0.00011.20 (0.77–1.88)0.41.97 (1.44–2.69)<0.0001
Model 3
Change in waist circumference1.52 (1.18–1.96)0.0011.82 (1.18–2.80)0.0071.49 (1.08–2.06)0.01
Change in weight1.48 (1.13–1.95)0.0051.04 (0.64–1.70)0.91.79 (1.29–2.50)0.0006
• Model 1 = adjusted for sex, family history of diabetes, and baseline age, current smoking, physical activity, fasting glucose, and hypertension. Model 2 = model 1 + change in fasting insulinemia. Model 3 = model 1 + change in HOMA2-IR.

• *SDs for the standardization of the odds ratios in all IFG participants, BMI <25 kg/m2group, and BMI ≥25 kg/m2 group were, respectively, 0.78, 0.74, and 0.82 cm/year for change in waist circumference and 0.71, 0.62, and 0.77 kg/year for change in weight.