Table 16

Table of drugs to treat symptomatic DPN

ClassExamplesTypical doses*
Tricyclic drugsAmitriptyline10–75 mg at bedtime
Nortriptyline25–75 mg at bedtime
Imipramine25–75 mg at bedtime
AnticonvulsantsGabapentin300–1,200 mg t.i.d.
Carbamazepine200–400 mg t.i.d.
Pregabalin†100 mg t.i.d.
5-Hydroxytryptamine and norepinephrine uptake inhibitorDuloxetine†60–120 mg daily fs
Substance P inhibitorCapsaicin cream0.025–0.075% applied t.i.d.-q.i.d.
  • *Dose response may vary; initial doses need to be low and titrated up.

  • †Has FDA indication for treatment of painful diabetic neuropathy.