Conditional logistic regression model of cardiovascular events, stratified by subgroup
Subgroup | n | A1C (%) | Odds ratio (95% CI)* | P |
---|---|---|---|---|
LDL <100, no other CV drug† | 20,871 | ≤6 | 1.39 (1.15–1.67) | 0.0006 |
>8 | 1.20 (1.03–1.40) | 0.02 | ||
LDL >100, no other CV drug† | 13,983 | ≤6 | 1.05 (0.79–1.39) | 0.74 |
>8 | 1.41 (1.18–1.69) | 0.0002 | ||
On other cardiovascular drug, LDL <100† | 9,555 | ≤6 | 1.10 (0.85–1.43) | 0.45 |
>8 | 1.25 (0.95–1.63) | 0.11 | ||
On other cardiovascular drug, LDL >100† | 4,038 | ≤6 | 0.89 (0.39–2.01) | 0.78 |
>8 | 1.32 (0.70–2.49) | 0.39 | ||
Patients using antipsychotics‡ | 2,539 | ≤6 | 1.05 (0.53–2.07) | 0.90 |
>8 | 3.15 (1.18- 8.44) | 0.02 | ||
Patients not using antipsychotics† | 53,246 | ≤6 | 1.26 (1.15–1.38) | <0.0001 |
>8 | 1.17 (1.09–1.26) | <0.0001 |
LDL units are in mg/dl. Other cardiovascular drugs include antiplatelets and antihypertensives other than ACE inhibitors and ARBs.
↵*Odds ratio for A1C category compared with A1C 6–8% (reference).
↵†Not on antipsychotics. Model controlled for number of A1C tests in the 3-year index period, A1C range, diabetes medications, proportion of days covered of diabetes medications, use of statins, ACE inhibitors, ARBs, antiarrhythmics, tricyclic antidepressants, ESAs, β-agonists, diagnosis of hypertension, heart failure or peripheral vascular disease, retinopathy, nephropathy, neuropathy, prior cardiovascular events in 3-year preindex period, and severe hypoglycemia.
↵‡Model controlled for prior cardiovascular events, HDL level, use of β-agonists, and ESAs.