Table 2

Crude and adjusted RORs for any infection

ROR (95% CI)
DrugReports (N)Reports of infections (N)CrudeAdjusted*
Biguanides21,763289ReferenceReference
SU derivatives16,6752581.2 (1.0–1.4)1.1 (0.9–1.3)
TZDs57,8149191.2 (1.1–1.4)1.3 (1.1–1.5)
DPP-4 I8,0832422.3 (1.9–2.7)2.3 (1.9–2.9)
Insulins80,3471,7031.6 (1.4–1.8)1.5 (1.3–1.7)
OAD + OAD11,9911551.0 (0.8–1.2)0.9 (0.7–1.1)
OAD + insulin2,066481.8 (1.3–2.4)1.5 (1.1–2.2)
≥3 ADs2,924391.0 (0.7–1.4)1.1 (0.9–1.4)
  • ADs, antidiabetic drugs; DPP-4 I, dipeptidyl peptidase inhibitors; OAD, oral antidiabetic drug; SU, sulfonylurea; TZD, thiazolidinediones.

  • *Adjusted for age, sex, reporting year, reporting region, reporter type, and comedication affecting the immune system: antibiotics (J01), corticosteroids for systemic use (H02), and immunosuppressants (L04).