Overnight glucose control using FreeStyle Navigator continuous glucose monitor and the MPC algorithm in women with type 1 diabetes during early and late pregnancy
| Variable | Early pregnancy | Late pregnancy | P value |
|---|---|---|---|
| Median plasma glucose, mg/dL | |||
| At start of night (2300 h) | 102.6 (100.8–142.2) | 113.4 (86.4–122.4) | 0.51 |
| Overnight (2300–0700 h) | 109.8 (82.8–131.4) | 109.8 (99–113.4) | 0.57 |
| SD overnight plasma glucose | 14.4 (10.8–21.6) | 16.2 (12.6–23.4) | 0.28 |
| Time in target (63–140 mg/dL), % | 84 (50–100) | 100 (94–100) | 0.09 |
| Nocturnal hypoglycemia | |||
| % Time hypoglycemic <63 mg/dL | 0 (0–3) | 0 (0–0) | 0.18 |
| % Time hypoglycemic ≤50 mg/dL* | 0 (0–0) | 0 (0–0) | 0.32 |
| Nocturnal hyperglycemia | |||
| % Time hyperglycemic >140 mg/dL | 7 (0–40) | 0 (0–6) | 0.25 |
| % Time hyperglycemic ≥180 mg/dL | 0 (0–0) | 0 (0–0) | 0.32 |
| Blood glucose index | |||
| Low | 0.9 (0.0–4.3) | 1.1 (0.2–2.7) | 0.80 |
| High | 0.3 (0.0–1.3) | 0.2 (0.1–0.5) | 0.51 |
| Mean insulin infusion, units/kg | 0.5 (0.4–0.8) | 0.6 (0.4–1.1) | 0.80 |
| SD insulin infusion rate | 0.5 (0.4–0.6) | 0.6 (0.5–0.7) | 0.11 |
Values are given as median (interquartile range).
↵*There was one episode of unexplained nocturnal hypoglycemia in early pregnancy (CGM glucose 63 mg/dL, plasma glucose 46.8 mg/dL) at 0500 h despite only 0.4 units of basal insulin infused during the preceding 6 h (insulin infusion rate 0.066 units/h).