Table 2

Glucose metabolism, insulin sensitivity, and secretion (all expressed as means ± SD) in women with pGDM and their insulin-resistant (pGDM-IR) and insulin-sensitive (pGDM-IS) subgroups compared with control subjects (CON)

pGDMpGDM-IRpGDM-ISCONP
N231498
Fasting glucose (mg/dL)90 ± 992.3 ± 1186.3 ± 384 ± 9NS*NSNSNS§
Fasting insulin (µU/mL)9.8 ± 5.711.6 ± 6.57.2 ± 2.57.6 ± 1.6NS*NS
Fasting C-peptide (ng/mL)1.89 ± 0.982.26 ± 1.121.37 ± 0.422.00 ± 0.43NS*<0.05
QUICKI0.348 ± 0.0270.337 ± 0.0240.364 ± 0.0240.357 ± 0.018NS*<0.05
1-h glucose (mg/dL)OGTT144 ± 42155 ± 44126 ± 32106 ± 47NS*NS0.04NS§
2-h glucose (mg/dL)OGTT109 ± 32117 ± 3998 ± 1285 ± 220.05*NSNSNS§
Fasting FFA (µmol/L)OGTT551 ± 206522 ± 150597 ± 277659 ± 256NS*NS
2-h FFA (mmol/L)OGTT33 ± 1839 ± 1923 ± 1242 ± 25NS*<0.04NSNS§
AUCGLUC (mol/L min)1.21 ± 0.131.30 ± 0.081.10 ± 0.071.07 ± 0.16NS*<0.05
AUCINS (nmol/L min)61.75 ± 41.074.76 ± 47.841.52 ± 12.450.39 ± 41.6NS*<0.05
  • IR was defined by means of OGIS <462.8 mL ⋅ min−1 ⋅ m−2.

  • Fasting FFA, basal free fatty acid; 2-h FFA, free fatty acid at 120 min; QUICKI, quantitative insulin-sensitivity check index; AUCGLUC, area under the glucose concentration curve; AUCINS, area under the insulin concentration curve.

  • *pGDM vs. CON.

  • †pGDM-IR vs. pGDM-IS.

  • ‡pGDM-IR vs. CON.

  • §pGDM-IS vs. CON.