Table 3

Associations between plasma AGEs and potential mechanisms linking AGEs to incident CVD and all-cause mortality (n = 339)

Dependent variableAll
β95% CIP value
Baseline eGFRMDRD
 Model 1−0.32−0.42 to 0.23<0.001
 Model 2−0.29−0.39 to −0.20<0.001
Ln-UAE rate
 Model 1−0.07−0.12 to −0.020.008
 Model 2−0.04−0.09 to 0.000.071
Inflammatory score
 Model 10.06−0.02 to 0.140.123
 Model 20.090.01–0.170.036
Endothelial dysfunction score
 Model 10.130.03–0.220.008
 Model 20.130.03–230.009
Pulse pressure
 Model 10.03−0.08 to 0.140.591
 Model 20.03−0.07 to 0.120.615
  • β, standardized regression coefficient indicates change in dependent variable (in SD) per 1 SD increase in baseline AGEs score. Model 1, adjusted for age, sex, duration of diabetes, case-control status, and A1C; model 2, model 1 + BMI, smoking status, MAP, total cholesterol, use of RAAS inhibitors, other antihypertensive treatment, and continuation of medication at baseline examination.