Table 3

Impact of NPR3 genetic variants and clinical variables on SPB (mmHg) from the DIABHYCAR and D2NG/SDG studies (multivariate analysis)

DIABHYCARP valueD2NG/SDGP value
Estimate ± SEEstimate ± SE
Sex (compared with male)1.9 ± 0.50.0004−1.5 ± 0.90.1058
Age (for each increment of 1 year)0.2 ± 0.1<0.00010.3 ± 0.04<0.0001
BMI (for each increment of 1 kg/m2)0.3 ± 0.1<0.00010.3 ± 0.10.0003
rs6889608*1.2 ± 0.50.0087−0.5 ± 0.70.5189
rs1173773*−0.9 ± 0.40.01411.4 ± 0.70.0296
rs2270915*1.1 ± 0.50.01631.7 ± 0.80.0306
  • *For each addition of a minor allele (i.e., C, G, and G for rs6889608, rs1173773, rs2270915, respectively).