Table 4

Clinical and biological response to salt reduction in the functional study

VariableSalt dietAA (n = 7)P valueG carriers (n = 7)Genotype effect (P value)Global genotype effect (P value)
UNa (mmol/24 h)Usual215 ± 91232 ± 850.7490.51
Low103 ± 65121 ± 690.565
 Treatment effect (P value)0.0180.018
 Global treatment effect (P value)0.0010.949*
SBP (mmHg)Usual144.6 ± 14.3137.4 ± 7.70.3380.51
Low124.2 ± 11.0134.2 ± 7.70.096
 Treatment effect (P value)0.0180.40
 Global treatment effect (P value)0.0060.006*
Ualb (mg/24 h)Usual233 (419)282 (405)0.6550.97
Low178 (239)239 (456)0.655
 Treatment effect (P value)0.0180.40
 Global treatment effect (P value)0.0130.048*
NT-proBNP (pg/mL)Usual97 (141)147 (651)0.3380.07
Low46 (149)95 (181)0.227
 Treatment effect (P value)0.1280.0425
 Global treatment effect (P value)0.0130.338*
  • Data are mean ± SD or median (interquartile range).

  • Treatment effect corresponds to the effect of the dietary salt restriction.

  • UNa, urinary sodium excretion; Ualb, urinary albumin excretion.

  • *P values for estimated genotype-treatment interaction.