Table 2

Derivative control of β-cell function in patients of the VNDS according to genotype of GCKR variants

GCKR SNPnMAFAAABBBβSEP value
rs67179804870.32657.6 ± 52.2639.4 ± 47.0643.4 ± 102.90.140.210.52
rs10498174860.35649.6 ± 52.3612 ± 48.5736.5 ± 91.60.160.210.45
rs65476264920.34645.4 ± 50.3609.1 ± 49.3744.2 ± 619.80.160.200.42
rs7800944920.47620.8 ± 66.3634.8 ± 49.6676.2 ± 57.50.190.190.33
rs23846284930.46558.1 ± 54.3651.8 ± 45.8760.6 ± 88.70.430.200.03
rs87314830.21652.9 ± 42.8635.6 ± 58.8716.1 ± 160.8−0.020.240.95
  • Data are presented as mean ± SE. Variables were log-transformed before statistical analysis to approximate a Gaussian distribution; the coefficient β and its SE refer to log-transformed values. The analysis was performed adjusting for age, sex, and BMI.

  • A, major allele; B, minor allele; MAF, minor allele frequency.