Table 1

ROR of bladder cancer for antidiabetic drugs

Active substanceCases*All ADRROR95% CIP
Pioglitazone3137,8414.302.82–6.52<0.001
Insulin29124,8731.010.06–1.550.961
Metformin25138,9000.730.46–1.150.158
Glimepiride1335,3881.660.89–3.010.080
Exenatide8100,9460.300.14–0.640.001
Gliclazide67,5603.561.42–8.390.001
Glipizide534,8160.610.22–1.540.272
Sitagliptin411,6381.510.48–4.220.416
Acarbose43,4795.121.61–14.33<0.001
Rosiglitazone444,0060.380.12–1.050.045
Glibenclamide338,2140.330.08–1.060.043
Nateglinide24,9941.75N.A.N.A.
Repaglinide26,0601.44N.A.N.A.
Phenformin16568.30N.A.N.A.
Voglibose12,9381.48N.A.N.A.
Other antidiabetic drugs07,367N.A.N.A.N.A.
Total138599,085
  • ADR, adverse drug reaction; N.A., not available.

  • *Cases of bladder cancer.

  • †Mantel-Haenszel corrected.