Table 3

Association between metabolic dysregulation measures and markers of brain aging after exclusion of participants with clinical diabetes*

VariableHOMA-IR (mmol/L × µU/mL)PFasting insulin (μU/mL)PHbA1c (%)P
TCBV−0.10 ± 0.03<0.001−0.03 ± 0.01<0.0010.02 ± 0.120.859
HV0.000 ± 0.0010.7840.000 ± 0.0000.5430.000 ± 0.0020.999
Verbal memory0.008 ± 0.0090.4050.001 ± 0.0020.574−0.035 ± 0.0430.404
Visual memory−0.011 ± 0.0090.193−0.004 ± 0.0020.1320.000 ± 0.0431.000
Executive function−0.026 ± 0.0090.003−0.007 ± 0.0020.002−0.102 ± 0.0420.016
  • Values in boldface type are significant.

  • *Adjusted for age, sex, and education (for cognitive measures).