Table 2

Mean systemic and renal hemodynamic function in hyperfiltering and normofiltering participants

Hyperfilterers (n = 10)Normofilterers (n = 8)
ParameterBaselineFollow-upBaselineFollow-up
Peripheral vascular parameters
 Heart rate (bpm)69 ± 865 ± 1072 ± 1171 ± 9
 Blood pressure (mmHg)
  Systolic112 ± 8112 ± 7114 ± 12112 ± 12
  Diastolic61 ± 361 ± 464 ± 462 ± 5
 Mean arterial pressure (mmHg)78 ± 480 ± 478 ± 779 ± 6
 Augmentation index (%)1.2 ± 11.7−11.0 ± 7.8*14.3 ± 14.02.5 ± 14.6*
Renal hemodynamic function
 ERPF (mL/min/1.73 m2)713 ± 120654 ± 111664 ± 114689 ± 124
 GFR (mL/min/1.73 m2)171 ± 20120 ± 15*120 ± 6125 ± 13
 FF0.24 ± 0.060.18 ± 0.03*0.18 ± 0.030.19 ± 0.03
 RBF (mL/min/1.73 m2)1,145 ± 861,063 ± 2001,073 ± 1591,072 ± 191
 RVR (mmHg/L/min)0.0678 ± 0.01350.0783 ± 0.0121*0.0745 ± 0.01180.0780 ± 0.0159
Circulating RAS mediators
 Plasma renin activity (ng/L/s)0.40 ± 0.310.24 ± 0.300.35 ± 0.400.63 ± 0.40
 Angiotensin II (pmol/L)4.3 ± 2.02.7 ± 2.52.8 ± 2.71.5 ± 2.6
 Aldosterone (pmol/L)155 ± 12244 ± 43*126 ± 5034 ± 23*
  • Data are shown as the mean ± SD.

  • *P ≤ 0.030 for the within-group change in parameter vs. baseline.

  • P ≤ 0.033 for the change in hemodynamic parameter in hyperfiltering vs. normofiltering subjects.

  • P ≤ 0.010 for the between-group difference in baseline parameter in normofiltering vs. hyperfiltering subjects.