Table 3

ORs and 95% CIs for the association between NAFLD improvement and T2DM incidence among participants with NAFLD at the first examination, stratified by BMI change

Participants with NAFLD at baseline (n = 728)BMI increase (n = 438)BMI decrease (n = 290)
CrudeMultivariate adjustedMultivariate adjustedMultivariate adjusted
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
NAFLD improvement0.31 (0.14–0.69)0.00420.27 (0.12–0.61)0.00170.40 (0.051–3.10)0.380.18 (0.069–0.46)<0.001
Age (continuous)*1.03 (1.00–1.07)0.0401.06 (1.02–1.11)0.00531.00 (0.95–1.05)0.91
Women*1.00 (0.54–1.87)1.001.15 (0.50–2.61)0.740.71 (0.25–1.98)0.51
BMI (continuous)*1.06 (0.98–1.15)0.131.07 (0.97–1.18)0.191.05 (0.93–1.19)0.46
IFG*3.25 (2.08–5.07)<0.0012.24 (1.25–4.01)0.00696.21 (2.84–13.58)<0.001
Family history of diabetes*2.28 (1.40–3.71)0.00102.19 (1.13–4.26)0.0212.27 (1.05–4.92)0.038
DL*1.77 (1.08–2.89)0.0242.06 (1.04–4.07)0.0381.63 (0.77–3.45)0.20
HT*0.99 (0.59–1.65)0.961.14 (0.59–2.20)0.710.79 (0.33–1.88)0.59
Physical exercise*0.92 (0.44–1.93)0.820.90 (0.32–2.51)0.841.38 (0.44–4.34)0.58
Physical exercise at follow-up0.64 (0.36–1.16)0.140.73 (0.31–1.70)0.460.48 (0.20–1.11)0.087
  • Logistic regression models were used to estimate the ORs, 95% CIs, and P values. NAFLD improvement was defined as NAFLD at baseline but not at the second health check. BMI change means change in BMI between the first and second health checks.

  • *These characteristics were based on information at baseline.