Table 2

Adjusted HRs and 95% CIs for CVD, CHD, stroke, and HF by category of A1C and FPG

Model 1*Model 2Model 3Model 4§
Outcome by category of A1C
 CVD
  <5%1 (referent)1 (referent)1 (referent)1 (referent)
  5 to <5.5%1.29 (1.04, 1.61)1.22 (0.98, 1.51)1.18 (0.94, 1.47)1.17 (0.94, 1.46)
  5.5 to <6%1.21 (0.95, 1.55)1.14 (0.89, 1.46)1.09 (0.85, 1.40)1.09 (0.85, 1.39)
  6 to <6.5%1.30 (0.91, 1.85)1.17 (0.82, 1.68)1.14 (0.79, 1.63)1.13 (0.79, 1.61)
  ≥6.5%1.93 (1.43, 2.59)1.80 (1.32, 2.44)1.50 (1.10, 2.04)1.40 (1.02, 1.93)
  Known diabetes3.60 (3.01, 4.31)3.38 (2.80, 4.08)2.52 (2.06, 3.08)2.31 (1.84, 2.90)
  C statistic0.692620.711770.719410.71886
 CHD
  <5%1 (referent)1 (referent)1 (referent)1 (referent)
  5 to <5.5%1.33 (1.03, 1.72)1.24 (0.95, 1.61)1.20 (0.93, 1.56)1.20 (0.92, 1.56)
  5.5 to <6%1.20 (0.90, 1.61)1.10 (0.82, 1.48)1.06 (0.79, 1.43)1.06 (0.79, 1.43)
  6 to <6.5%1.24 (0.81, 1.91)1.09 (0.70, 1.69)1.06 (0.68, 1.64)1.05 (0.68, 1.64)
  ≥6.5%1.89 (1.32, 2.70)1.72 (1.19, 2.49)1.43 (0.98, 2.08)1.38 (0.94, 2.04)
  Known diabetes3.91 (3.15, 4.84)3.67 (2.93, 4.59)2.76 (2.17, 3.51)2.64 (2.02, 3.45)
  C statistic0.696220.726130.732840.73230
 Stroke
  <5%1 (referent)1 (referent)1 (referent)1 (referent)
  5 to <5.5%1.22 (0.77, 1.94)1.13 (0.71, 1.81)1.10 (0.69, 1.76)1.09 (0.68, 1.74)
  5.5 to <6%1.80 (1.13, 2.87)1.70 (1.06, 2.72)1.63 (1.02, 2.62)1.60 (1.00, 2.57)
  6 to <6.5%1.42 (0.70, 2.88)1.34 (0.66, 2.73)1.28 (0.63, 2.60)1.24 (0.61, 2.53)
  ≥6.5%2.62 (1.49, 4.62)2.62 (1.47, 4.66)2.24 (1.26, 3.99)1.93 (1.06, 3.52)
  Known diabetes3.22 (2.20, 4.73)3.1 (2.12, 4.69)2.37 (1.56, 3.61)1.93 (1.21, 3.10)
  C statistic0.693340.720590.734130.73602
 HF
  <5%1 (referent)1 (referent)1 (referent)1 (referent)
  5 to <5.5%1.38 (0.87, 2.19)1.29 (0.81, 2.05)1.23 (0.78, 1.96)1.23 (0.77, 1.95)
  5.5 to <6%1.12 (0.66, 1.91)1.06 (0.62, 1.81)1.01 (0.59, 1.73)1.00 (0.59, 1.71)
  6 to <6.5%2.23 (1.20, 4.13)2.00 (1.08, 3.72)1.88 (1.01, 3.50)1.86 (1.00, 3.46)
  ≥6.5%2.20 (1.20, 4.03)2.10 (1.14, 3.87)1.58 (0.84, 2.95)1.49 (0.78, 2.83)
  Known diabetes5.07 (3.48, 7.39)4.39 (2.97, 6.48)2.84 (1.89, 4.29)2.68 (1.72, 4.19)
  C statistic0.728410.739590.756590.75730
By category of FPG
 CVD
  <100 mg/dL1 (referent)1 (referent)1 (referent)1 (referent)
  100 to <126 mg/dL1.16 (0.96, 1.41)1.13 (0.92, 1.37)1.10 (0.90, 1.34)1.10 (0.90, 1.34)
  ≥126 mg/dL1.51 (1.18, 1.92)1.45 (1.13, 1.86)1.30 (1.01, 1.67)1.25 (0.97, 1.62)
  Known diabetes3.41 (2.87, 4.05)3.28 (2.73, 3.94)2.45 (2.02, 2.99)2.27 (1.81, 2.86)
  C statistic0.691050.711060.719130.71937
 CHD
  <100 mg/dL1 (referent)1 (referent)1 (referent)1 (referent)
  100 to <126 mg/dL1.28 (1.01, 1.62)1.22 (0.96, 1.55)1.20 (0.95, 1.53)1.20 (0.95, 1.52)
  ≥126 mg/dL1.53 (1.13, 2.05)1.43 (1.06, 1.94)1.28 (0.94, 1.74)1.27 (0.92, 1.73)
  Known diabetes3.89 (3.15, 4.80)3.74 (3.00, 4.68)2.84 (2.24, 3.60)2.78 (2.11, 3.66)
  C statistic0.695190.725540.732560.73263
 Stroke
  <100 mg/dL1 (referent)1 (referent)1 (referent)1 (referent)
  100 to <126 mg/dL1.08 (0.73, 1.58)1.04 (0.70, 1.54)1.01 (0.68, 1.50)0.99 (0.67, 1.47)
  ≥126 mg/dL1.71 (1.08, 2.71)1.72 (1.08, 2.75)1.55 (0.97, 2.48)1.35 (0.83, 2.20)
  Known diabetes2.65 (1.88, 3.74)2.65 (1.84, 3.81)1.98 (1.34, 2.92)1.51 (0.95, 2.39)
  C statistic0.689410.715320.730170.73329
 HF
  <100 mg/dL1 (referent)1 (referent)1 (referent)1 (referent)
  100 to <126 mg/dL0.84 (0.57, 1.24)0.83 (0.56, 1.24)0.80 (0.54, 1.19)0.80 (0.53, 1.19)
  ≥126 mg/dL1.43 (0.90, 2.29)1.39 (0.87, 2.23)1.16 (0.71, 1.87)1.09 (0.66, 1.78)
  Known diabetes3.78 (2.74, 5.20)3.37 (2.40, 4.74)2.19 (1.52, 3.14)1.94 (1.28, 2.96)
  C statistic0.727450.739580.755870.75658
  • Data are HR (95% CI). The models were run separately for each category of A1C and FPG.

  • *Adjusted for age and sex.

  • †Adjusted for variables in model 1, plus LDL cholesterol, HDL cholesterol, hypertension (yes vs. no), systolic blood pressure, and smoking status (current, past, and never).

  • ‡Adjusted for variables in model 2, plus log(urinary albumin-to-creatinine ratio).

  • §Adjusted for variables in model 3, plus baseline FPG for category of A1C or baseline A1C for category of FPG.