Table 2

Adjusted* ORs (95% CIs) of incident diabetes according to quintiles of plasma concentrations of PCBs, organochlorine pesticides, and summary measures of PCBs or organochlorine pesticides

Quintiles of plasma concentrations of POPs
Q1Q2Q3Q4Q5Ptrend
PCBs congener (number of chlorine atoms)
 PCB74 (4)
  Cases/n at risk1/1368/1498/15111/1448/145
  Adjusted OR (95% CI)Reference7.7 (0.9–64.1)8.5 (1.0–71.8)11.5 (1.4–94.9)9.0 (1.0–78.6)0.05
 PCB99 (5)
  Cases/n at risk2/1425/1538/14514/1487/137
  Adjusted OR (95% CI)Reference2.5 (0.5–13.5)4.3 (0.9–21.2)6.9 (1.5–31.6)3.3 (0.6–17.3)0.04
 PCB105 (5)
  Cases/n at risk0/13412/1587/1488/1489/137
  Adjusted OR (95% CI)Reference10.7 (1.3–84.4)7.0 (0.8–59.3)7.5 (0.9–63.6)8.0 (0.9–68.2)0.30
 PCB118 (5)
  Cases/n at risk2/1419/1526/14311/1508/138
  Adjusted OR (95% CI)Reference4.0 (0.8–19.2)2.9 (0.6–15.1)5.2 (1.1–25.5)3.6 (0.7–18.8)0.19
 PCB138 (6)
  Cases/n at risk3/1504/1537/14814/1358/139
  Adjusted OR (95% CI)Reference1.5 (0.3–7.0)2.5 (0.6–10.1)5.9 (1.6–21.7)3.2 (0.8–13.2)0.01
 PCB153 (6)
  Cases/n at risk5/1494/1526/14814/1367/140
  Adjusted OR (95% CI)Reference0.8 (0.2–3.2)1.5 (0.4–5.1)3.4 (1.1–10.2)1.7 (0.5–6.2)0.06
 PCB156 (6)
  Cases/n at risk4/1477/1539/1429/1407/143
  Adjusted OR (95% CI)Reference2.1 (0.6–7.6)3.2 (0.9–11.1)3.0 (0.8–10.8)2.6 (0.7–10.3)0.14
 PCB157 (6)
  Cases/n at risk4/1527/1487/14010/1398/146
  Adjusted OR (95% CI)Reference2.1 (0.6–7.4)2.3 (0.6–8.4)3.5 (1.0–12.4)2.9 (0.8–10.9)0.07
 PCB170 (7)
  Cases/n at risk3/1546/14311/14510/1476/136
  Adjusted OR (95% CI)Reference2.8 (0.7–11.9)5.6 (1.4–21.8)5.0 (1.2–20.5)3.6 (0.8–16.8)0.06
 PCB180 (7)
  Cases/n at risk3/18010/1476/1449/1428/139
  Adjusted OR (95% CI)Reference4.6 (1.2–17.8)2.8 (0.7–12.1)4.6 (1.1–18.8)4.8 (1.1–20.9)0.07
 PCB189 (7)
  Cases/n at risk4/1396/14411/1518/1537/138
  Adjusted OR (95% CI)Reference1.9 (0.5–7.1)3.5 (1.0–11.9)2.9 (0.8–10.9)2.8 (0.7–11.2)0.12
 PCB194 (8)
  Cases/n at risk4/1415/14911/1555/14111/139
  Adjusted OR (95% CI)Reference1.4 (0.4–5.6)3.5 (1.0–11.7)2.2 (0.5–9.0)6.0 (1.6–22.9)<0.01
 PCB206 (9)
  Cases/n at risk3/1468/1436/15310/1399/144
  Adjusted OR (95% CI)Reference3.2 (0.8–12.7)2.1 (0.5–9.0)5.5 (1.4–21.9)5.0 (1.2–21.1)0.02
 PCB209 (10)
  Cases/n at risk2/1418/14812/1476/1438/146
  Adjusted OR (95% CI)Reference3.9 (0.8–19.1)7.1 (1.5–33.0)3.8 (0.7–20.2)6.2 (1.2–33.0)0.06
Organochlorine pesticides
 p,p’-DDE
  Cases/n at risk5/1494/1488/1478/14311/138
  Adjusted OR (95% CI)Reference0.8 (0.2–2.9)1.4 (0.4–4.5)1.4 (0.4–4.4)2.1 (0.7–6.3)0.11
Trans-nonachlor
  Cases/n at risk4/1485/1462/14717/1478/137
  Adjusted OR (95% CI)Reference1.2 (0.3–4.7)0.5 (0.1–2.6)4.2 (1.3–13.3)1.8 (0.5–6.8)0.03
 Hexachlorobenzene
  Cases/n at risk5/1435/14910/1495/13411/150
  Adjusted OR (95% CI)Reference1.0 (0.3–3.5)1.9 (0.6–5.9)1.1 (0.3–4.2)2.1 (0.6–7.1)0.21
Summary measure
 All 14 PCBs
  Cases/n at risk2/1506/1407/14612/1479/142
  Adjusted OR (95% CI)Reference4.5 (0.9–23.5)5.1 (1.0–26.0)8.8 (1.8–42.7)7.5 (1.4–38.8)<0.01
 All 3 organochlorine pesticides
  Cases/n at risk4/1525/1517/1426/13914/141
  Adjusted OR (95% CI)Reference1.1 (0.3–4.5)1.6 (0.4–5.8)1.5 (0.4–5.8)3.4 (1.0–11.7)0.03
  • *Adjusted for sex, BMI, cigarette smoking, exercise, alcohol consumption, triglycerides, and total cholesterol.

  • †PCB105 had zero cases in the lowest quintile; for statistical assessment, we artificially added one case to that quintile so that OR estimates were not infinite; covariates were evaluated at the median values of noncases in the lowest quintile.